Seeber S, Schmidt C G
Klin Wochenschr. 1977 Dec 1;55(23):1127-36. doi: 10.1007/BF01478050.
Praetherapeutic sensitivity tests of human solid tumours based on incorporation studies of nucleic acid precursors have been described by various authors. This review intends to show that such tests may only be of rather limited value for the design of individual chemotherapeutic regimens. In many drugs, a correlation between biochemical and clinical effects has not yet been established. The reliability of praetherapeutic sensitivity tests is further impaired by general methodological difficulties of short-term cultures, individual pharmacology and toxicology of cytostatic agents as well as pharmacological and biochemical drug interactions in combination chemotherapy. Praetherapeutic testing with individual cytostatic drugs is discussed.
多位作者描述了基于核酸前体掺入研究的人类实体瘤治疗前敏感性测试。本综述旨在表明，此类测试对于个体化化疗方案的设计可能价值相当有限。在许多药物中，生化效应与临床效应之间的相关性尚未确立。治疗前敏感性测试的可靠性因短期培养的一般方法学困难、细胞毒性药物的个体药理学和毒理学以及联合化疗中的药理和生化药物相互作用而进一步受损。本文讨论了使用个体细胞毒性药物进行治疗前测试的情况。
