Geller Ron, Adams Erin J, Guethlein Lisbeth A, Little Ann-Margaret, Madrigal J Alejandro, Parham Peter
Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305-5126, USA.
Immunogenetics. 2002 Jun;54(3):212-5. doi: 10.1007/s00251-002-0452-x. Epub 2002 Apr 11.
Patr-AL is a recently described gene found only in the common chimpanzee, but closely related in structure to the highly polymorphic Patr-A and HLA-A genes of the chimpanzee and human MHCs, respectively. Unlike Patr-A and HLA-A, the Patr-AL gene has little polymorphism and is not fixed in the chimpanzee genome. To determine whether Patr-AL is located in the MHC or elsewhere, we compared segregation of the Patr-AL gene with segregation of Patr-A and - B alleles in chimpanzee families. The results demonstrate that Patr-AL is an MHC class I gene present on different MHC haplotypes as defined by their combination of Patr-A and B alleles.
Patr-AL是最近发现的一个基因，仅在普通黑猩猩中存在，但其结构分别与黑猩猩主要组织相容性复合体（MHC）中高度多态的Patr-A基因以及人类MHC中的HLA-A基因密切相关。与Patr-A和HLA-A不同，Patr-AL基因几乎没有多态性，并且在黑猩猩基因组中也不是固定不变的。为了确定Patr-AL基因是位于MHC中还是其他位置，我们将Patr-AL基因的分离情况与黑猩猩家族中Patr-A和 -B等位基因的分离情况进行了比较。结果表明，Patr-AL是一种MHC I类基因，存在于由Patr-A和B等位基因组合所定义的不同MHC单倍型上。
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