Bertazzolo W, Zuliani D, Pogliani E, Caniatti M, Bussadori C
Pronto Soccorso Veterinario, Lodi, Italy.
J Small Anim Pract. 2002 Jun;43(6):265-8. doi: 10.1111/j.1748-5827.2002.tb00071.x.
An eight-year-old female German wirehaired pointer was presented with signs of respiratory distress. Clinical examination, laboratory results, thoracic radiography and echocardiography indicated the presence of a diffuse interstitial lung disease with secondary appropriate erythrocytosis, pulmonary hypertension and cor pulmonale. Transthoracic fine needle aspiration biopsy of the lung suggested malignant epithelial neoplasia. A primary lung cancer with an unusually diffuse distribution of miliary/micronodular lesions was found at postmortem examination. Histological diagnosis was bronchiolo-alveolar carcinoma. Bronchiolo-alveolar carcinoma can occasionally occur in a diffuse fashion involving most or all of the lung parenchyma. In man, diffuse bronchiolo-alveolar carcinoma is considered a great imitator of other, more common diffuse interstitial forms of lung disease. This case report indicates that it is also a differential diagnosis to consider in dogs.
一只八岁雌性德国刚毛指示犬出现呼吸窘迫症状。临床检查、实验室检查结果、胸部X光片和超声心动图显示存在弥漫性间质性肺病，并伴有继发性真性红细胞增多症、肺动脉高压和肺源性心脏病。经胸肺细针穿刺活检提示为恶性上皮性肿瘤。尸检发现原发性肺癌，伴有粟粒状/微小结节病变异常弥漫分布。组织学诊断为细支气管肺泡癌。细支气管肺泡癌偶尔可呈弥漫性发生，累及大部分或全部肺实质。在人类中，弥漫性细支气管肺泡癌被认为是其他更常见的弥漫性间质性肺病的重要模仿者。本病例报告表明，在犬类中也应考虑将其作为鉴别诊断。
