Milon H, Atkinson J
Arzneimittelforschung. 1979;29(11):1724-7.
The interaction of caffeine and hexobarbital in the rat with spinal cord transection was studied. Duration of hexobarbital effect on the brain was taken as the time from the injection of hexobarbital (i.v.) to the return of pre-injection cortical voltage. Hexobarbital distribution and elimination was estimated by application of a two-compartmental model to values for blood hexobarbital concentration (determined by a direct gas chromatographic method after extraction). Caffeine caused a shift in the dose-response curve for hexobarbital but no changes in hexobarbital distribution and elimination. Results are interpreted on the basis of a central interaction of caffeine with hexobarbital at a brain receptor level.
研究了咖啡因与己巴比妥在脊髓横断大鼠体内的相互作用。己巴比妥对脑的作用持续时间定义为从静脉注射己巴比妥到注射前皮质电压恢复的时间。通过将二室模型应用于血中己巴比妥浓度值（提取后用直接气相色谱法测定）来估计己巴比妥的分布和消除。咖啡因使己巴比妥的剂量反应曲线发生偏移，但对己巴比妥的分布和消除无影响。结果基于咖啡因与己巴比妥在脑受体水平的中枢相互作用进行解释。
