Mundt Arno J, Roeske John C, Lujan Anthony E
Department of Radiation and Cellular Oncology, The University of Chicago, IL 60637, USA.
Med Dosim. 2002 Summer;27(2):131-6. doi: 10.1016/s0958-3947(02)00095-x.
Radiation therapy (RT) is commonly used in the treatment of gynecologic malignancies. Unfortunately, RT exposes patients to a wide variety of sequelae. Concerns over toxicity also limit the use of higher doses in select patients. To improve the efficacy of conventional RT and to explore the possibility of dose escalation, we have turned to the use of intensity-modulated RT (IMRT). This report reviews our preclinical studies, implementation, and clinical experience to date with IMRT for gynecologic malignancies.
放射治疗（RT）常用于妇科恶性肿瘤的治疗。不幸的是，放射治疗会使患者面临各种各样的后遗症。对毒性的担忧也限制了在特定患者中使用更高剂量。为了提高传统放射治疗的疗效并探索剂量递增的可能性，我们已转向使用调强放射治疗（IMRT）。本报告回顾了我们迄今为止对妇科恶性肿瘤使用调强放射治疗的临床前研究、实施情况及临床经验。
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