Griffiths E C
Horm Res. 1976;7(3):179-91. doi: 10.1159/000178727.
With the structural characterization of the hypothalamic hormones, luteinizing hormone-releasing hormone (LH-RH), thyrotrophin-releasing (TRH), melanocyte-stimulating hormone release-inhibiting hormine (MIH), and growth hormone release-inhibiting hormone, (GH-RIH or somatostatin), it has been possible to investigate their enzymic inactivation by peptidases which are present at various sites in the body. Enzymes may play an important part in the control of polypeptide hormone levels and the peptidases acting on these four hypothalamic hormones may regulate the amount of TRH, LH-RH, MIH and somatostatin released from the hypothalamus, or their action at the level of the pituitary and their removal from the circulation. By studying the peptidase enzymes, further information may be obtained on the physiological mechanisms controlling the secretion and actions of hypothalamic hormones, as well as on the design of analogues with increased or competitive activity.
随着下丘脑激素促黄体生成激素释放激素（LH - RH）、促甲状腺激素释放激素（TRH）、促黑素细胞激素释放抑制激素（MIH）以及生长激素释放抑制激素（GH - RIH或生长抑素）的结构得以明确，人们得以研究存在于身体各个部位的肽酶对它们的酶促失活作用。酶可能在多肽激素水平的调控中发挥重要作用，作用于这四种下丘脑激素的肽酶可能会调节从下丘脑释放的TRH、LH - RH、MIH和生长抑素的量，或者它们在垂体水平的作用以及它们从循环中的清除。通过研究肽酶，或许可以获得更多关于控制下丘脑激素分泌和作用的生理机制的信息，以及关于具有增强活性或竞争性活性类似物设计的信息。
