DMLE+：贝叶斯连锁不平衡基因定位
DMLE+: Bayesian linkage disequilibrium gene mapping.
作者信息
Reeve Jeff P, Rannala Bruce
机构信息
Department of Medical Genetics, University of Alberta, 8-39 Medical Sciences Building, Edmonton, Canada.
出版信息
Bioinformatics. 2002 Jun;18(6):894-5. doi: 10.1093/bioinformatics/18.6.894.
SUMMARY
The program DMLE+ allows Bayesian inference of the location of a gene carrying a mutation influencing a discrete trait (such as a disease) and/or other parameters of interest (such as mutation age) based on the observed linkage disequilibrium at multiple genetic markers. DMLE+ uses either individual marker genotypes, or haplotypes, integrates over uncertain population allele frequencies, and can incorporate prior information about gene location from an annotated human genome sequence.
AVAILABILITY
DMLE+ is available in both Windows GUI and portable UNIX command line versions at http://dmle.org.
摘要
程序DMLE+允许基于在多个遗传标记处观察到的连锁不平衡，对携带影响离散性状（如疾病）的突变基因的位置和/或其他感兴趣的参数（如突变年龄）进行贝叶斯推断。DMLE+使用单个标记基因型或单倍型，对不确定的群体等位基因频率进行整合，并且可以纳入来自注释人类基因组序列的关于基因位置的先验信息。
可用性
DMLE+有适用于Windows GUI和便携式UNIX命令行版本，可在http://dmle.org获取。
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