AbrB是枯草芽孢杆菌中σ（W）调控子的一个调节因子。
AbrB is a regulator of the sigma(W) regulon in Bacillus subtilis.
作者信息
Qian Qiang, Lee Chien Y, Helmann John D, Strauch Mark A
机构信息
Department of Oral and Craniofacial Biological Sciences, Dental School, University of Maryland, 666 W. Baltimore St., Room 4-C-30, Baltimore, MD 21201, USA.
出版信息
FEMS Microbiol Lett. 2002 Jun 4;211(2):219-23. doi: 10.1111/j.1574-6968.2002.tb11228.x.
The Bacillus subtilis global regulator AbrB was found to negatively control expression of sigW and genes of the sigma(W) regulon. AbrB bound to DNA regions in the autoregulatory sigW promoter and to some, but not all, of the other sigma(W)-dependent promoters in B. subtilis. Defects in antibiotic resistance properties caused by spo0A mutations are at least partially correlated with AbrB repression of the sigma(W) regulon.
枯草芽孢杆菌全局调控因子AbrB被发现对sigW及σ（W）调控子基因的表达起负调控作用。AbrB与枯草芽孢杆菌中sigW自身调控启动子的DNA区域以及部分（但并非全部）其他依赖σ（W）的启动子结合。由spo0A突变导致的抗生素抗性特性缺陷至少部分与AbrB对σ（W）调控子的抑制相关。
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