Spo0A在遗传感受态中的主要作用是下调abrB，abrB是一种关键的感受态基因。
The major role of Spo0A in genetic competence is to downregulate abrB, an essential competence gene.
作者信息
Hahn J, Roggiani M, Dubnau D
机构信息
Public Health Research Institute, New York, New York 10016, USA.
出版信息
J Bacteriol. 1995 Jun;177(12):3601-5. doi: 10.1128/jb.177.12.3601-3605.1995.
Abstract
We show that the major role for Spo0A in the development of genetic competence is to downregulate expression of abrB. AbrB is both a negative regulator and a positive regulator of competence. The negative effects are exerted at multiple points in competence regulation. A regulatory mechanism that is independent of mecA and abrB operates on comK expression.
摘要
我们发现，Spo0A在遗传感受态发育中的主要作用是下调abrB的表达。AbrB既是感受态的负调节因子，也是正调节因子。其负效应在感受态调节的多个环节发挥作用。一种独立于mecA和abrB的调节机制作用于comK的表达。
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MecB of Bacillus subtilis, a member of the ClpC ATPase family, is a pleiotropic regulator controlling competence gene expression and growth at high temperature.枯草芽孢杆菌的MecB属于ClpC ATP酶家族成员，是一种多效调节因子，可控制感受态基因表达及高温下的生长。
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