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本文引用的文献

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Group II metabotropic glutamate receptor activation is required for normal hippocampal mossy fibre development in the rat.大鼠海马苔藓纤维正常发育需要II组代谢型谷氨酸受体激活。
J Physiol. 2002 Feb 15;539(Pt 1):157-62. doi: 10.1113/jphysiol.2001.013505.
2
Presynaptic inhibition of GABAergic miniature currents by metabotropic glutamate receptor in the rat CNS.大鼠中枢神经系统中代谢型谷氨酸受体对γ-氨基丁酸能微小电流的突触前抑制作用。
Neuroscience. 2002;109(2):299-311. doi: 10.1016/s0306-4522(01)00484-5.
3
Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function.代谢型谷氨酸受体1和5对CA1锥体细胞功能有不同的调节作用。
J Neurosci. 2001 Aug 15;21(16):5925-34. doi: 10.1523/JNEUROSCI.21-16-05925.2001.
4
G(alpha)q-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 region.G（α）q基因缺陷型小鼠缺乏代谢型谷氨酸受体依赖性长时程抑制，但在海马CA1区表现出正常的长时程增强。
J Neurosci. 2001 Jul 15;21(14):4943-8. doi: 10.1523/JNEUROSCI.21-14-04943.2001.
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Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1.海马CA1区中代谢型谷氨酸受体5及蛋白质合成依赖性长时程抑制的化学诱导
J Neurophysiol. 2001 Jul;86(1):321-5. doi: 10.1152/jn.2001.86.1.321.
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Groups II and III metabotropic glutamate receptors differentially modulate brief and prolonged nociception in primate STT cells.第二组和第三组代谢型谷氨酸受体对灵长类脊髓丘脑束（STT）细胞的短暂和持续性伤害感受具有不同的调节作用。
J Neurophysiol. 2000 Dec;84(6):2998-3009. doi: 10.1152/jn.2000.84.6.2998.
7
Calcineurin regulates ryanodine receptor/Ca(2+)-release channels in rat heart.钙调神经磷酸酶调节大鼠心脏中的兰尼碱受体/Ca(2+)释放通道。
Biochem J. 2000 Nov 15;352 Pt 1(Pt 1):61-70.
8
Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3-CA1 synapses.双丝裂原活化蛋白激酶途径介导CA3-CA1突触处相反形式的长期可塑性。
Nat Neurosci. 2000 Nov;3(11):1107-12. doi: 10.1038/80624.
9
A modulatory role for protein phosphatase 2B (calcineurin) in the regulation of Ca2+ entry.蛋白磷酸酶2B（钙调神经磷酸酶）在调节钙离子内流中起调节作用。
Eur J Neurosci. 2000 Aug;12(8):2881-91. doi: 10.1046/j.1460-9568.2000.00178.x.
10
Cocaine and kindling alter the sensitivity of group II and III metabotropic glutamate receptors in the central amygdala.可卡因与点燃效应会改变杏仁核中央核中II型和III型代谢型谷氨酸受体的敏感性。
J Neurophysiol. 2000 Aug;84(2):759-70. doi: 10.1152/jn.2000.84.2.759.

钙调神经磷酸酶在II型代谢型谷氨酸受体和NMDA受体依赖性长时程抑制中发挥不同作用。

Calcineurin plays different roles in group II metabotropic glutamate receptor- and NMDA receptor-dependent long-term depression.

作者信息

Li Sheng-Tian, Kato Kunio, Tomizawa Kazuhito, Matsushita Masayuki, Moriwaki Akiyoshi, Matsui Hideki, Mikoshiba Katsuhiko

机构信息

Mikoshiba Calciosignal Net Project, Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Tokyo 113-0021, Japan.

出版信息

J Neurosci. 2002 Jun 15;22(12):5034-41. doi: 10.1523/JNEUROSCI.22-12-05034.2002.

DOI:10.1523/JNEUROSCI.22-12-05034.2002
PMID:12077199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6757754/
Abstract

We investigated metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD) in hippocampal CA1 pyramidal neurons of 6- to 8-d-old [postnatal days 6-8 (P6-P8)] and 21- to 25-d-old (P21-P25) rats. In P6-P8 rats, induction of LTD depended on the activity of group II mGluRs. In P21-P25 rats, however, this LTD disappeared, and instead, NMDA receptor (NMDAR)-dependent LTD appeared. A bath containing a specific calcineurin (CaN) inhibitor restored the group II mGluR-dependent LTD in the neurons of the P21-P25 rats. Although postsynaptic injection of CaN inhibitors suppressed NMDAR-dependent LTD, it did not affect induction of group II mGluR-dependent LTD. These results demonstrate that CaN plays different roles in the induction of two forms of LTD: presynaptic CaN inhibits group II mGluR-dependent LTD, whereas postsynaptic CaN facilitates NMDAR-dependent LTD. These findings are the first demonstration in vitro of group II mGluR-dependent LTD that is negatively regulated by CaN via an age-dependent mechanism.

摘要

我们研究了6至8日龄[出生后第6至8天（P6 - P8）]和21至25日龄（P21 - P25）大鼠海马CA1锥体神经元中代谢型谷氨酸受体（mGluR）依赖性长时程抑制（LTD）。在P6 - P8大鼠中，LTD的诱导依赖于II组mGluR的活性。然而，在P21 - P25大鼠中，这种LTD消失了，取而代之的是出现了NMDA受体（NMDAR）依赖性LTD。含有特定钙调神经磷酸酶（CaN）抑制剂的浴液可恢复P21 - P25大鼠神经元中II组mGluR依赖性LTD。虽然突触后注射CaN抑制剂可抑制NMDAR依赖性LTD，但它不影响II组mGluR依赖性LTD的诱导。这些结果表明，CaN在两种形式的LTD诱导中发挥不同作用：突触前CaN抑制II组mGluR依赖性LTD，而突触后CaN促进NMDAR依赖性LTD。这些发现首次在体外证明了II组mGluR依赖性LTD通过年龄依赖性机制受到CaN的负调控。