Aste Nicola, Fumo Giuseppe, Contu Franca, Aste Natalia, Biggio Pietro
Department of Dermatology, Ospedale S. Giovanni de Dio, University of Cagliari, Via Ospedale 54, 09124-Cagliari, Italy.
J Am Acad Dermatol. 2002 Jul;47(1):146-7. doi: 10.1067/mjd.2002.120910.
We report a series of 9 patients, 6 men and 3 women, who presented nail hyperpigmentation arising between 6 and 24 months from the start of hydroxyurea therapy. The most commonly observed clinical pattern was that of longitudinal melanonychia. In only 1 patient, who was affected in all 20 nails, we observed longitudinal melanonychia, diffuse melanonychia, and hyperpigmentation of the skin.
我们报告了一组9例患者，其中男性6例，女性3例，他们在开始使用羟基脲治疗6至24个月后出现指甲色素沉着。最常见的临床模式是纵向黑甲。仅1例患者的所有20个指甲均受累，我们观察到其有纵向黑甲、弥漫性黑甲以及皮肤色素沉着。
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