Zhang D, Zhang X, Tang Z, Chen C, Chen Y, Yang W, Jin M, Huang C, Yang G, Long Y
Sichuan Institute of Parasitic Diseases, Chengdu 610041.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1998;16(1):1-5.
To study the anthelmintic effect of albendazole composite (containing 67 mg of albendazole and 83.3 mg base of pyrantel pamoate per tablet).
A randomized controlled study was carried out to compare the efficacy of a single dose of 3 or 2 tablets of albendazole composite versus a single dose of 400 mg of albendazole or 10 mg base/kg of pyrantel pamoate for treatment of intestinal nematodiasis including 1,864 cases infected with hookworm, 1,568 cases infected with Ascaris, 1,785 cases infected with Tricuris trichiura and 373 children infected with Enterobius vermicularis.
In adults, the egg negative conversion rate of a single dose of 3 or 2 tablets of albendazole composite reached 65.0% and 52.7% for hookworm infection (P < 0.01), 100% and 100% for Ascaris infection, and 26.5% and 19.2% for Trichuris infection (P < 0.01), respectively. There were significantly better effect against hookworm with 3 tablets of albendazole composite than that with single albendazole or pyrantel pamoate (65.0% vs. 47.6% and 38.5%, P < 0.01). The effect of 2 tablets of albendazole composite against hookworm was also higher than that of single pyrantel pamoate (P < 0.01) and equal to single albendazole but the anthelmintic effect against Trichuris infection was lower than that of single albendazole (19.2% vs. 26.5%). In 2-6-year-old children, the effect of 1.5 tablets of albendazole composite against Enterobius vermicularis infection showed an egg negative conversion rate of 100% which was higher than that of single pyrantel pamoate (100% vs. 83.0%, P < 0.01). The worm collection data showed that the worm-expelling action of albendazole composite was much more rapid than that of albendazole. There were no adverse effects of albendazole composite on blood picture, liver or renal function and ECG. The side effect of both 3 and 2 tablets of albendazole composite was mild and transcient.
Albendazole composite exhibits a synergistic effect of both albendazole and pyrantel pamoate.
研究阿苯达唑复方制剂（每片含阿苯达唑67mg和噻嘧啶碱基83.3mg）的驱虫效果。
开展一项随机对照研究，比较单剂量服用3片或2片阿苯达唑复方制剂与单剂量服用400mg阿苯达唑或10mg碱基/千克噻嘧啶治疗肠道线虫病的疗效，研究对象包括1864例钩虫感染者、1568例蛔虫感染者、1785例鞭虫感染者和373例蛲虫感染儿童。
在成人中，单剂量服用3片或2片阿苯达唑复方制剂治疗钩虫感染的虫卵转阴率分别达到65.0%和52.7%（P<0.01），蛔虫感染为100%和100%，鞭虫感染为26.5%和19.2%（P<0.01）。单剂量服用3片阿苯达唑复方制剂治疗钩虫感染的效果明显优于单剂量阿苯达唑或噻嘧啶（65.0%对47.6%和38.5%，P<0.01）。单剂量服用2片阿苯达唑复方制剂治疗钩虫感染的效果也高于单剂量噻嘧啶（P<0.01），与单剂量阿苯达唑相当，但治疗鞭虫感染的驱虫效果低于单剂量阿苯达唑（19.2%对26.5%）。在2至6岁儿童中，单剂量服用1.5片阿苯达唑复方制剂治疗蛲虫感染的虫卵转阴率为100%，高于单剂量噻嘧啶（100%对83.0%，P<0.01）。虫体收集数据显示，阿苯达唑复方制剂的驱虫作用比阿苯达唑快得多。阿苯达唑复方制剂对血常规、肝肾功能和心电图均无不良影响。单剂量服用3片和2片阿苯达唑复方制剂的副作用均轻微且短暂。
阿苯达唑复方制剂显示出阿苯达唑和噻嘧啶的协同作用。
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