Gan Y, Wu Q, Ou F, Li G, Huang J, Wei Q, Nong C, Nong L
Institute of Parasitic Diseases Control Guangxi Zhuang Autonomous Region, Nanning.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1994;12(2):147-9.
A single dose of albendazole (candy) 100 mg and 100 mg qd for two days was given respectively to 135 and 321 children who were infected with Enterobius vermicularis. All cases were cured 3wk later according to perianal tape examination. The same drug of 150 mg qd and 200 mg qd for two days was administered respectively to residents with single or multi-infections of Ascaris, hookworm and Trichuris; the egg negative conversion rates of the two dosages were revealed to be 99.4% (466/469) and 99.8% (487/488) for Ascaris infection, 96.8% (91/94) and 94.3% (99/105) for hookworm infection, and 53.4% (228/427) and 76.3% (370/486) for Trichuris infection. The maximal numbers of worm expelled were 100 on d2-3, 88 on d3-5 and 588 on d2-4 for Enterobius, Ascaris and hookworm, respectively; whereas the discharged Trichuris were scarce, merely 4.3 in average. The results exhibited promising efficacy of the drug on Enterobius, Ascaris and hookworm infections, but not so on trichuriasis.
分别给135名和321名感染蠕形住肠线虫的儿童单次服用100毫克阿苯达唑（糖剂），以及连续两天每天服用100毫克。3周后根据肛周胶带检查，所有病例均已治愈。分别给感染蛔虫、钩虫和鞭虫单重或多重感染的居民连续两天每天服用150毫克和200毫克同一药物；两种剂量对蛔虫感染的虫卵转阴率分别为99.4%（466/469）和99.8%（487/488），对钩虫感染的转阴率分别为96.8%（91/94）和94.3%（99/105），对鞭虫感染的转阴率分别为53.4%（228/427）和76.3%（370/486）。蠕形住肠线虫、蛔虫和钩虫排出虫体的最大数量分别在第2 - 3天为100条、第3 - 5天为88条和第2 - 4天为588条；而排出的鞭虫很少，平均仅4.3条。结果表明该药物对蠕形住肠线虫、蛔虫和钩虫感染有良好疗效，但对鞭虫病疗效不佳。
