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1997年1月至2001年1月冠状动脉杂交血运重建术:临床随访

Coronary hybrid revascularization from January 1997 to January 2001: a clinical follow-up.

作者信息

Riess Friedrich-Christian, Bader Ralf, Kremer Peter, Kühn Clemens, Kormann Joachim, Mathey Detlef, Moshar Sina, Tuebler Thilo, Bleese Niels, Schofer Joachim

机构信息

Heart Center Hamburg, Albertinen-Krankenhaus, Department of Cardiac Surgery, Hamburg-Othmarschen, Germany.

出版信息

Ann Thorac Surg. 2002 Jun;73(6):1849-55. doi: 10.1016/s0003-4975(02)03519-1.

Abstract

BACKGROUND

Hybrid revascularization (HyR), combining minimally invasive left internal mammary artery (LIMA) bypass grafting to the left anterior descending coronary artery (LAD) and catheter interventional treatment of the remaining coronary lesions, avoids the disadvantages associated with cardiopulmonary bypass (CPB). We investigated the clinical follow-up of 57 patients with multivessel disease undergoing this procedure in the last 4 years.

METHODS

Between January 1997 and January 2001, 57 consecutive patients (41 men and 16 women, aged 65.7 +/- 7.9 years) with coronary artery disease (two-vessel, n = 34; three-vessel, n = 23) were treated with off-pump LIMA-to-LAD bypass combined with balloon angioplasty and stenting of the remaining significantly obstructed (> 50%) coronary vessels. Clinical follow-up data included a early postoperative and a 6-month control angiography and a patient interview in January 2001.

RESULTS

All patients underwent LIMA-to-LAD bypass-grafting and balloon angioplasty in 72 coronary lesions without procedural-related complications. However, one early LIMA bypass occlusion was documented during coronary angiography. Postoperatively no deterioration of preexistent organ dysfunction was observed in any patient. The mean follow-up was 100.7 +/- 37.9 weeks in 55 of 57 patients (97%). Control angiography 6 months after HyR (n = 34) revealed a patent LIMA bypass in 33 patients and 8 in-stent restenoses (> 50%) in the coronary arteries that were treated interventionally by re-PTCA (n = 6) or by conventional CABG (n = 1). In 1 patient medical treatment resulted in significant reduction of angina so no further intervention was considered necessary. After HyR 1 patient died 18 months later of an intracerebral hemorrhage. All other patients are alive and doing well.

CONCLUSIONS

Our results indicate that in selected patients with multivessel disease including left main stem stenosis HyR is an effective and secure procedure with excellent early and good midterm results. Especially elderly patients with severe concomitant diseases appear to benefit from this approach by avoiding CPB.

摘要

背景

杂交血管重建术(HyR),即将微创左乳内动脉(LIMA)搭桥至左前降支冠状动脉(LAD)与对其余冠状动脉病变进行导管介入治疗相结合,避免了与体外循环(CPB)相关的缺点。我们对过去4年中接受该手术的57例多支血管病变患者进行了临床随访。

方法

1997年1月至2001年1月,连续57例冠心病患者(41例男性,16例女性,年龄65.7±7.9岁)(双支血管病变34例;三支血管病变23例)接受了非体外循环下LIMA至LAD搭桥术,并对其余严重阻塞(>50%)的冠状动脉进行球囊血管成形术和支架置入术。临床随访数据包括术后早期和6个月时的对照血管造影,以及2001年1月的患者访谈。

结果

所有患者均接受了LIMA至LAD搭桥术和对72处冠状动脉病变的球囊血管成形术,无手术相关并发症。然而,冠状动脉造影记录到1例早期LIMA搭桥闭塞。术后未观察到任何患者原有器官功能障碍恶化。57例患者中的55例(97%)平均随访时间为100.7±37.9周。HyR术后6个月(n = 34)的对照血管造影显示,33例患者的LIMA搭桥通畅,经再次PTCA(n = 6)或传统冠状动脉旁路移植术(CABG)(n = 1)干预治疗的冠状动脉中有8例发生支架内再狭窄(>50%)。1例患者经药物治疗后心绞痛明显减轻,因此无需进一步干预。HyR术后1例患者18个月后死于脑出血。所有其他患者均存活且情况良好。

结论

我们的结果表明,对于包括左主干狭窄在内的多支血管病变的特定患者,HyR是一种有效且安全的手术,具有优异的早期和良好的中期结果。尤其是患有严重合并症的老年患者似乎可通过避免CPB而从该方法中获益。

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