Fumarola D, Fransvea P, Telesforo P, Pasquetto N, Mazzone A, Miragliotta G
Minerva Chir. 1975 Oct 31;30(20):1040-8.
A detailed critical review on the role of endotoxins from gram-negative bacteria in the pathogenesis of most of the intestinal experimental models of surgical interest is presented. Data of an investigation on 10 cases of acute appendicitis and 2 cases of intestinal occlusion associated with toxaemia are then presented: in all these cases the Limulus test significatively revealed the presence of endotoxin in the blood and in the peritoneal fluid, also in absence of bacteria in the blood. The implications of these results and the use of the test in clinical practice are discussed.
本文详细批判性地综述了革兰氏阴性菌内毒素在大多数具有外科研究意义的肠道实验模型发病机制中的作用。随后展示了一项针对10例急性阑尾炎和2例伴有毒血症的肠梗阻病例的调查数据：在所有这些病例中，鲎试剂检测均显著显示血液和腹腔液中存在内毒素，即便血液中无细菌。讨论了这些结果的意义以及该检测在临床实践中的应用。
