Mellor R H, Stanton A W B, Menadue L, Levick J R, Mortimer P S
Division of Physiological Medicine (Dermatology Unit), St. George's Hospital Medical School, London, UK.
Microcirculation. 2002 Jul;9(3):207-19. doi: 10.1038/sj.mn.7800133.
To determine whether the skin expansion associated with breast cancer related lymphedema (BCRL) reduces microvessel density or causes a compensatory angiogenesis.
Dermal microvessel density was measured by simultaneous fluorescence video angiography in the ipsilateral and contralateral forearms of 25 patients treated for breast cancer, 12 with BCRL (excess volume 30 +/- 20%) and 13 without.
Microvessel density was as high in the swollen arm (27.2 +/- 7.2 mm(-2)) as in the contralateral arm (24.2 +/- 6.2 mm(-2)) despite a 16 +/- 12% increase in local circumference. Total microvessels in a 1-mm annulus of skin was 30% greater in the swollen arm (752 +/- 211) than the contralateral arm (578 +/- 157; p = 0.005, t-test). Microvessel density was similar in each arm in control patients (ipsilateral 24.1 +/- 6.2 mm(-2), contralateral 26.1 +/- 8.8 mm(-2)).
The number of microvessels increased in the expanded skin to maintain microvessel density at a normal level. Therefore, angiogenesis occurs during chronic limb swelling. The control group results indicate that angiogenesis is not caused by the cancer treatment.
确定与乳腺癌相关淋巴水肿（BCRL）相关的皮肤扩张是否会降低微血管密度或引发代偿性血管生成。
通过同步荧光视频血管造影术测量25例接受乳腺癌治疗患者同侧和对侧前臂的真皮微血管密度，其中12例患有BCRL（多余体积30±20%），13例未患。
尽管肿胀手臂的局部周长增加了16±12%，但其微血管密度（27.2±7.2mm⁻²）与对侧手臂（24.2±6.2mm⁻²）一样高。肿胀手臂1mm皮肤环内的微血管总数（752±211）比对侧手臂（578±157；p = 0.005，t检验）多30%。对照患者双臂的微血管密度相似（同侧24.1±6.2mm⁻²，对侧26.1±8.8mm⁻²）。
扩张皮肤中的微血管数量增加，以将微血管密度维持在正常水平。因此，慢性肢体肿胀期间会发生血管生成。对照组结果表明血管生成不是由癌症治疗引起的。
