Tan B, Cao P, Qi Z
Department of Hematology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Hunan Yi Ke Da Xue Xue Bao. 1999;24(4):371-3.
To investigate the role of calcitonin(CT) gene hypermethylation in the transformation from the initial chronic phase to blast crisis of chronic myeloid leukemia, 31 CML patients were studied by using Hpa II-PCR. The results showed that the 10.52%(2/19) chronic phase, 71.4%(5/7) accelerated phase and 80.0%(4/5) blast crisis of patients had CT gene hypermethylation and that the increased methylation of the CT gene were related with the disease progression. The reports indicated that the hypermethylation of CT gene might be a useful marker for predicting the evolution of CML and selecting chronic phase patients for BMT.
为探讨降钙素（CT）基因高甲基化在慢性髓性白血病从慢性期向急变期转化中的作用，采用Hpa II-PCR方法对31例慢性髓性白血病患者进行研究。结果显示，慢性期患者CT基因高甲基化率为10.52%（2/19），加速期为71.4%（5/7），急变期为80.0%（4/5），CT基因甲基化程度增加与疾病进展相关。报告指出，CT基因高甲基化可能是预测慢性髓性白血病病情演变及选择慢性期患者进行骨髓移植的有用标志物。
