Rasmussen G Lynn, Steckner Karen, Hogue Charles, Torri Sarah, Hubbard Richard C
Total Joint Replacement, Orthopedic Specialty Hospital, Murray, Utah, USA.
Am J Orthop (Belle Mead NJ). 2002 Jun;31(6):336-43.
Our objective in a randomized, multicenter, double-blind, parallel-group, placebo- and active-controlled study was to evaluate and compare the analgesic effectiveness of single intravenous (IV) doses of parecoxib sodium 20 and 40 mg, morphine 4 mg, and ketorolac 30 mg in the postsurgical orthopedic pain model. After undergoing unilateral total knee replacement surgery, 208 healthy adult patients were randomized to receive placebo or a study drug within 6 hours of discontinuation of patient-controlled analgesia on postoperative day 1. Onset of analgesia was similarly rapid with IV parecoxib sodium 40 mg, morphine, and ketorolac. Level and duration of analgesia were significantly superior with parecoxib sodium than with morphine and were similar for parecoxib sodium and ketorolac. Parecoxib sodium was safe and well tolerated. In conclusion, IV parecoxib sodium 40 mg is as effective as ketorolac 30 mg and is more effective than morphine 4 mg and therefore has potential widespread utility in acute postoperative pain management.
在一项随机、多中心、双盲、平行组、安慰剂对照和阳性对照研究中，我们的目的是评估和比较单剂量静脉注射（IV）20毫克和40毫克帕瑞昔布钠、4毫克吗啡以及30毫克酮咯酸在术后骨科疼痛模型中的镇痛效果。208名健康成年患者在接受单侧全膝关节置换手术后，于术后第1天停用患者自控镇痛6小时内随机接受安慰剂或一种研究药物。静脉注射40毫克帕瑞昔布钠、吗啡和酮咯酸的镇痛起效同样迅速。帕瑞昔布钠的镇痛强度和持续时间显著优于吗啡，且与酮咯酸相似。帕瑞昔布钠安全且耐受性良好。总之，静脉注射40毫克帕瑞昔布钠与30毫克酮咯酸效果相当，且比4毫克吗啡更有效，因此在急性术后疼痛管理中具有潜在的广泛应用价值。
