Jenson Hal B, Gauntt Charles J, Easley Kirk A, Pitt Jane, Lipshultz Steven E, McIntosh Kenneth, Shearer William T
Department of Pediatrics, MC 7811, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
J Infect Dis. 2002 Jun 15;185(12):1798-802. doi: 10.1086/340819. Epub 2002 May 31.
In a matched case-control study of the association between coxsackieviruses and cardiac impairment, 24 human immunodeficiency virus (HIV) type 1-infected children with cardiac impairment were compared with 24 HIV-1-infected control subjects. Serologic evidence of coxsackievirus infection was present in all children, with no significant difference in geometric mean antibody titers between case patients and control subjects. Conditional logistic regression to test for an association between coxsackievirus antibody titer and the presence or absence of cardiac impairment, by any indicator, showed an odds ratio of 1.11 (95% confidence interval, 0.58-2.10; P=.75), indicating no association between coxsackievirus infection and cardiac impairment. Coxsackievirus antibody titers correlated positively with total IgG levels in nonrapid progressors but not in rapid progressors. Paired serum samples taken before and after diagnosis of cardiac impairment in 5 patients showed no evidence of intervening coxsackievirus infection. These results do not identify a causal role for coxsackieviruses for cardiomyopathy in HIV-1-infected children.
在一项关于柯萨奇病毒与心脏损害之间关联的配对病例对照研究中，将24名感染1型人类免疫缺陷病毒（HIV）且有心脏损害的儿童与24名HIV-1感染的对照受试者进行了比较。所有儿童均有柯萨奇病毒感染的血清学证据，病例患者与对照受试者之间的几何平均抗体滴度无显著差异。通过条件逻辑回归来检验柯萨奇病毒抗体滴度与任何指标所显示的心脏损害的存在与否之间的关联，结果显示比值比为1.11（95%置信区间，0.58 - 2.10；P = 0.75），表明柯萨奇病毒感染与心脏损害之间无关联。在非快速进展者中，柯萨奇病毒抗体滴度与总IgG水平呈正相关，但在快速进展者中并非如此。对5例患者在心脏损害诊断前后采集的配对血清样本未显示有柯萨奇病毒感染介入的证据。这些结果并未确定柯萨奇病毒在HIV-1感染儿童的心肌病中具有因果作用。
