变形链球菌的毒力：突变分离株的生化及致病特性

Virulence of Streptococcus mutans: biochemical and pathogenic characteristics of mutant isolates.

作者信息

Michalek S M, Shiota T, Ikeda T, Navia J M, McGhee J R

出版信息

Proc Soc Exp Biol Med. 1975 Nov;150(2):498-502. doi: 10.3181/00379727-150-39064.

PMID:1208567

Abstract

The in vitro dextran-sucrase activities and adherence to glass of S. mutans 6715 and PS14 wild types and mutants were quantitated and compared with their in vivo cariogenicity in young, gnotobiotic rats. In general, S. mutans PS14 mutants B414 and B421 and 6715 mutant C4 demonstrated less dextran-sucrase activity and adherence than parental strains and caused fewer carious lesions in gnotobiotic rats. Rats monoinfected with either PS14 mutants B414 or B421 had less plaque and viable S. mutans in plaque than rats infected with parental strain. Both S. mutans 6715 mutants C211 and C229, demonstrated greater enzyme activity and adherence than the parental strain and produced more carious lesions.

摘要

对变形链球菌6715和PS14野生型及其突变体的体外葡聚糖蔗糖酶活性和对玻璃的黏附性进行了定量，并与它们在幼年无菌大鼠体内的致龋性进行了比较。总体而言，变形链球菌PS14突变体B414和B421以及6715突变体C4的葡聚糖蔗糖酶活性和黏附性低于亲本菌株，并且在无菌大鼠中引起的龋损较少。单感染PS14突变体B414或B421的大鼠，其牙菌斑和菌斑中活的变形链球菌比感染亲本菌株的大鼠少。变形链球菌6715突变体C211和C229的酶活性和黏附性均高于亲本菌株，并且产生了更多的龋损。