Humphreys M H, Reid I A, Ufferman R C, Lieberman R A, Earley L E
Proc Soc Exp Biol Med. 1975 Dec;150(3):728-34. doi: 10.3181/00379727-150-39115.
The effect of altered tubular sodium reabsorption on renin secretion (RSR) was examined under conditions in which other factors influencing renin release could be controlled or excluded. To do this, isolated canine kidneys were perfused at constant pressure with blood circulating from donor animals. Volume expansion or hemorrhage of the donor dogs produced large changes in the animal's blood pressure, renal function, sodium excretion (UNaV), and RSR, but were without effect on renal hemodynamics, UNaV, or RSR in the perfused kidney. Hemodilution without volume expansion, resulted in hypotension, decreased UNaV and increased RSR in the donor dogs, and increased UNaV and suppressed RSR in the perfused kidney. These effects of hemodilution in the perfused kidney were partially reversed when plasma protein concentration was restored to control levels with hyperoncotic albumin, and, overall, there was a significant inverse relationship between electrolyte excretion and RSR. These results provide new evidence for the hypothesis that the rate at which sodium is delivered to the macula densa is an important determinant of the rate of renin secretion.
在能够控制或排除其他影响肾素释放的因素的条件下，研究了肾小管钠重吸收改变对肾素分泌（RSR）的影响。为此，用来自供体动物循环的血液在恒压下灌注离体犬肾。供体犬的容量扩张或出血会使动物的血压、肾功能、钠排泄（UNaV）和RSR发生很大变化，但对灌注肾的肾血流动力学、UNaV或RSR没有影响。无容量扩张的血液稀释导致供体犬低血压、UNaV降低和RSR增加，而灌注肾中UNaV增加且RSR受到抑制。当用高渗白蛋白将血浆蛋白浓度恢复到对照水平时，灌注肾中血液稀释的这些影响部分得到逆转，总体而言，电解质排泄与RSR之间存在显著的负相关关系。这些结果为以下假设提供了新的证据，即输送到致密斑的钠速率是肾素分泌速率的重要决定因素。
