Sardiñas M A, Cárdenas A Z, Marie G C, Peña M S, Santiago M A, Sanchez M V, Farrington C P
Direccion Nacional de Epidemiologia, MINSAP, Ciudad de la Habana, Cuba.
Eur J Epidemiol. 2001;17(8):783-7. doi: 10.1023/a:1015675932509.
Two exploratory investigations found an increased risk of intussusception after oral polio vaccine (OPV). A large, national, population-based study was undertaken in Cuba to investigate a possible association. Three hundred and thirty-five cases of intussusception in children under 2 years of age occurring in 1995-2000 were identified and their OPV records retrieved. The relative incidence (RI) of intussusception in defined periods up to 42 days after OPV in children under 1 year was estimated using the self-controlled case series method, controlling for age and season. The RI was not significantly raised in any of the time intervals examined within the 0-42 day period after OPV. For the period 0-42 days as a whole the RI was 1.11, 95% CI 0.74-1.67. This study does not support the hypothesis that OPV causes intussusception.
两项探索性调查发现口服脊髓灰质炎疫苗（OPV）后肠套叠风险增加。古巴开展了一项大规模、基于全国人口的研究以调查可能的关联。确定了1995年至2000年期间发生的335例2岁以下儿童肠套叠病例，并检索了他们的OPV记录。使用自控病例系列方法，在控制年龄和季节的情况下，估算了1岁以下儿童在OPV后长达42天的特定时间段内肠套叠的相对发病率（RI）。在OPV后0至42天内检查的任何时间间隔内，RI均未显著升高。整个0至42天期间的RI为1.11，95%置信区间为0.74至1.67。本研究不支持OPV导致肠套叠的假设。
