Houser V, Cash R J, Van Hart D A
Pharmacol Biochem Behav. 1975 Sep-Oct;3(5):825-31. doi: 10.1016/0091-3057(75)90113-6.
Eighty rats were housed in standard activity wheel cages and fed for only 1 hr per day. The animals were divided into 10-animal drug groups that received either 0.25, 050, 1.0 mg/kg of scopolamine methylbromide, or 0.06, 0.125, 0.250 mg/kg of carbachol, 3 times a day. Two separate 10-animal saline control groups accompaned each drug series. All animals died within 6 days and most demonstrated significant gastric lesions in the glandular fundus of the stomach. All dosages of scopolamine methylbromide significantly reduced the number and severity of gastric lesions and in some cases abolished all signs of stomach pathology. None of the dosages of carbachol significantly affected either the number of degree of gastric ulceration noted in the body of the stomach. These results were interpreted to suggest that the secretion of gastric acid may be an important contributing factor in the formation of gastric ulcers in animals subjected to the activity-stress procedure.
80只大鼠饲养在标准的活动轮式笼子里，每天仅喂食1小时。将这些动物分成每组10只的药物组，分别给予0.25、0.50、1.0毫克/千克的甲溴东莨菪碱，或0.06、0.125、0.250毫克/千克的卡巴胆碱，每天3次。每个药物系列配有两个单独的每组10只动物的生理盐水对照组。所有动物均在6天内死亡，大多数在胃腺胃底部出现明显的胃部病变。所有剂量的甲溴东莨菪碱均显著减少了胃部病变的数量和严重程度，在某些情况下消除了所有胃部病理迹象。卡巴胆碱的所有剂量均未对胃体部出现的胃溃疡的数量或程度产生显著影响。这些结果被解释为表明，胃酸分泌可能是在经历活动应激程序的动物中形成胃溃疡的一个重要促成因素。
