Preparation of polymer-supported benzyllithium reagents.
作者信息
Itsuno Shinichi, Tanaka Satoshi, Hirao Akira
机构信息
Department of Materials Science, Toyohashi University of Technology, Japan.
出版信息
Bioorg Med Chem Lett. 2002 Jul 22;12(14):1853-6. doi: 10.1016/s0960-894x(02)00274-3.
Abstract
Cross-linked polystyrenes (2, 8, and 11) possessing pendant double bonds conjugated with benzene ring were prepared by both polymerization method and chemical modification of pre-formed polymers. These double bonds were readily lithiated with n-butyllithium to give the benzyllithium species on the polymer. The polymer supported benzylic anions (3 and 12) are a versatile polymeric organometallic reagent that reacted with various kinds of electrophiles.
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