Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Org Lett. 2010 Feb 5;12(3):588-91. doi: 10.1021/ol902784q.
Union of type II Anion Relay Chemistry (ARC) with Pd-induced Cross Coupling Reactions (CCR) has been achieved, in conjunction with the design, synthesis, and evaluation of a new class of bifunctional linchpins, comprising a series of vinyl silanes bearing beta- or gamma-electrophilic sites. The synthetic tactic permits both alkylation and Pd-mediated CCR of the anions derived via 1,4-silyl C(sp(2))-->O Brook Rearrangements.
实现了 II 型阴离子接力化学（ARC）与钯诱导交叉偶联反应（CCR）的结合，同时设计、合成并评估了一类新型双功能连接子，包括一系列带有β-或γ-亲电子位点的乙烯基硅烷。该合成策略允许通过 1,4-硅基 C(sp(2))-->O Brook 重排得到的阴离子进行烷基化和钯介导的 CCR。
