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Pancreatic cancer: from genes to patient care.

作者信息

Hruban R H

机构信息

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231-2410, USA.

出版信息

J Gastrointest Surg. 2001 Nov-Dec;5(6):583-7. doi: 10.1016/s1091-255x(01)80099-8.

DOI:10.1016/s1091-255x(01)80099-8
PMID:12086895
Abstract
摘要

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Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors.白藜芦醇通过激活 FOXO 转录因子抑制原位胰腺肿瘤的生长。
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Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors.

本文引用的文献

1
Increased risk of incident pancreatic cancer among first-degree relatives of patients with familial pancreatic cancer.家族性胰腺癌患者一级亲属患胰腺癌的风险增加。
Clin Cancer Res. 2001 Mar;7(3):738-44.
2
Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation.新型分泌粒细胞巨噬细胞集落刺激因子的胰腺癌同种异体肿瘤疫苗：安全性和免疫激活的I期试验
J Clin Oncol. 2001 Jan 1;19(1):145-56. doi: 10.1200/JCO.2001.19.1.145.
3
Predicting lung cancer by detecting aberrant promoter methylation in sputum.
二吲哚甲烷类似物激活核 TR3（NR4A1）可诱导胰腺癌细胞和肿瘤中的细胞凋亡和促凋亡基因。
Carcinogenesis. 2011 Jun;32(6):836-42. doi: 10.1093/carcin/bgr040. Epub 2011 Mar 1.
4
Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.姜黄素通过抑制 NFkappaB 和胰腺癌细胞及肿瘤生长取决于特异性蛋白下调。
J Biol Chem. 2010 Aug 13;285(33):25332-44. doi: 10.1074/jbc.M109.095240. Epub 2010 Jun 9.
5
Structure-dependent activation of endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer by 1,1-bis(3'-indoly)-1-(p-substituted phenyl)methanes.1,1-双（3'-吲哚基）-1-（对-取代苯基）甲烷对胰腺癌内质网应激介导的细胞凋亡的结构依赖性激活作用
Mol Cancer Ther. 2008 Oct;7(10):3363-72. doi: 10.1158/1535-7163.MCT-08-0439.
6
Loss of expression of antigen-presenting molecules in human pancreatic cancer and pancreatic cancer cell lines.人类胰腺癌及胰腺癌细胞系中抗原呈递分子表达的缺失。
Clin Exp Immunol. 2007 Apr;148(1):127-35. doi: 10.1111/j.1365-2249.2006.03289.x.
通过检测痰液中异常的启动子甲基化来预测肺癌。
Cancer Res. 2000 Nov 1;60(21):5954-8.
4
Progression model for pancreatic cancer.胰腺癌进展模型
Clin Cancer Res. 2000 Aug;6(8):2969-72.
5
Hypermethylation of multiple genes in pancreatic adenocarcinoma.胰腺腺癌中多个基因的高甲基化
Cancer Res. 2000 Apr 1;60(7):1835-9.
6
Pancreaticoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma: comparison of morbidity and mortality and short-term outcome.胰十二指肠切除术联合或不联合扩大腹膜后淋巴结清扫术治疗壶腹周围腺癌：发病率、死亡率及短期疗效比较
Ann Surg. 1999 May;229(5):613-22; discussion 622-4. doi: 10.1097/00000658-199905000-00003.
7
Periampullary adenocarcinoma: analysis of 5-year survivors.壶腹周围腺癌：5年生存者分析
Ann Surg. 1998 Jun;227(6):821-31. doi: 10.1097/00000658-199806000-00005.
8
DNA content and other factors associated with ten-year survival after resection of pancreatic carcinoma.胰腺癌切除术后的DNA含量及与十年生存率相关的其他因素。
J Surg Oncol. 1998 Mar;67(3):151-9. doi: 10.1002/(sici)1096-9098(199803)67:3<151::aid-jso2>3.0.co;2-8.
9
Identifying markers for pancreatic cancer by gene expression analysis.通过基因表达分析鉴定胰腺癌的标志物。
Cancer Epidemiol Biomarkers Prev. 1998 Feb;7(2):109-12.
10
Gene expression profiles in normal and cancer cells.正常细胞和癌细胞中的基因表达谱。
Science. 1997 May 23;276(5316):1268-72. doi: 10.1126/science.276.5316.1268.