Chhetri Dinesh K, Blumin Joel H, Shapiro Nina L, Berke Gerald S
Division of Head and Neck Surgery, UCLA School of Medicine, 90095, USA.
Otolaryngol Head Neck Surg. 2002 Jun;126(6):642-8. doi: 10.1067/mhn.2002.125604.
Our aim was to report our experience with office-based treatment of severe laryngeal papillomatosis with percutaneous injection of cidofovir in a case series of 5 patients.
We conducted a retrospective review of a case series in a tertiary academic care voice disorders clinic. Adult patients with papillomas of the vocal cords and anterior commissure received percutaneous injection using a point-touch technique. Clinical improvement or remission of the papillomatosis was noted.
Before initiation of office treatments, patients required direct laryngoscopy and CO(2) laser ablation of papillomas on average every 2.8 months. There were no complications related to the injection technique. During a treatment period of 7 to 16 months (mean 12 months), a significant reduction in the volume of papillomatosis was achieved in all patients. One patient received 2 treatments and another received 1 treatment in the operating room for final clearance of papillomas.
Office-based treatment of adult patients with anterior laryngeal papillomatosis using percutaneous injection of cidofovir reduces the need for repeated direct laryngoscopy and laser ablation under general anesthesia.
Percutaneous injection treatment with cidofovir is a useful adjunct to direct laryngoscopy and laser ablation in the treatment of laryngeal papillomatosis.
我们的目的是报告在一个包含5例患者的病例系列中，经皮注射西多福韦对严重喉乳头状瘤病进行门诊治疗的经验。
我们对一家三级学术医疗嗓音障碍诊所的病例系列进行了回顾性研究。声带和前联合处有乳头状瘤的成年患者采用点触技术进行经皮注射。记录乳头状瘤病的临床改善或缓解情况。
在开始门诊治疗前，患者平均每2.8个月需要进行一次直接喉镜检查和二氧化碳激光切除乳头状瘤。注射技术未出现并发症。在7至16个月（平均12个月）的治疗期内，所有患者的乳头状瘤病体积均显著减小。一名患者接受了2次治疗，另一名患者在手术室接受了1次治疗以最终清除乳头状瘤。
经皮注射西多福韦对成年前喉部乳头状瘤病进行门诊治疗，减少了全身麻醉下重复进行直接喉镜检查和激光切除的必要性。
西多福韦经皮注射治疗是直接喉镜检查和激光切除治疗喉乳头状瘤病的一种有用辅助手段。
