Koźma Ewa M, Olczyk Krystyna, Bobiński Rafał, Kasperczyk Mariusz, Szpyra Katarzyna
Katedra i Zakład Chemii Klinicznej i Diagnostyki Laboratoryjnej, Slaska Akademia Medyczna, Sosnowiec.
Chir Narzadow Ruchu Ortop Pol. 2002;67(1):73-9.
Dupuytren's disease is a palmar fibromatosis bringing about irreversible finger contracture. Histopathologically, the disease is characterized by the presence of the two types of structures: nodules, containing of intensively proliferating cells, and fibrous cords, formed by thick bundles of collagen fibers. It seems that key role in the development of Dupuytren's contracture play alterations of palmar fibroblasts activity. These cells begin intensively proliferate and transform to myofibroblasts. The later ones sharing phenotypic features of fibroblasts and smooth muscle cells take part in remodelling of extracellular matrix and are a source of palmar contracture. The pivotal factors involved in changes of palmar fibroblasts functions seem to be growth factors (mainly TGF beta, PDGF and bFGF). However, the participation of reactive forms of oxygen in mentioned process is also considered.
掌腱膜挛缩症是一种导致不可逆手指挛缩的掌部纤维瘤病。在组织病理学上，该疾病的特征是存在两种结构：结节，由密集增殖的细胞组成；以及纤维索，由厚束状胶原纤维形成。掌腱膜挛缩症的发展中，掌部成纤维细胞活性的改变似乎起着关键作用。这些细胞开始大量增殖并转化为肌成纤维细胞。后者兼具成纤维细胞和平滑肌细胞的表型特征，参与细胞外基质的重塑，是掌部挛缩的根源。掌部成纤维细胞功能变化所涉及的关键因素似乎是生长因子（主要是转化生长因子β、血小板衍生生长因子和碱性成纤维细胞生长因子）。然而，也有人认为活性氧形式参与了上述过程。
