[与系统性红斑狼疮相关的抗磷脂综合征及原发性抗磷脂综合征中的可溶性黏附分子]
[Soluble adhesion molecules in antiphospholipid syndrome associated with systemic lupus erythematosus and in primary antiphospholipid syndrome].
作者信息
Aleksandrova E N, Novikov A A, Reshetniak T M, Kliukvina N G, Reshetniak D V, Samsonov M Iu, Nasonov E L
出版信息
Ter Arkh. 2002;74(5):23-7.
AIM
To evaluate clinical implications of measurements of the level of soluble cell molecules of adhesion (sCMA) in systemic lupus erythematosus (SLE) with antiphospholipid syndrome (APS) and primary APS (PAPS).
MATERIAL AND METHODS
Serum levels of sP-selectine, sE-selectine, sVCAM-1 were determined with enzyme immunoassay (R&D, USA) in 23 SLE with APS, 15 SLE patients free of APS and 19 patients with PAPS.
RESULTS
Mean levels of sE-selectine and sVCAM-1 in SLE patients with APS, PAPS and SLE was higher than in donors. Elevated mean levels of sP-selectine were observed only in SLE patients free of APS. These patients also showed a correlation between sVCAM-1 level and the disease activity (p < 0.01).
CONCLUSION
The development of immunopathological process in APS is associated with increased concentration of sCMA.
目的
评估抗磷脂综合征（APS）和原发性抗磷脂综合征（PAPS）患者系统性红斑狼疮（SLE）中可溶性细胞黏附分子（sCMA）水平测量的临床意义。
材料与方法
采用酶免疫分析法（美国R&D公司）测定23例合并APS的SLE患者、15例无APS的SLE患者及19例PAPS患者血清中sP-选择素、sE-选择素、sVCAM-1水平。
结果
合并APS的SLE患者、PAPS患者及SLE患者血清中sE-选择素和sVCAM-1的平均水平高于健康对照者。仅在无APS的SLE患者中观察到sP-选择素平均水平升高。这些患者还显示sVCAM-1水平与疾病活动度之间存在相关性（p<0.01）。
结论
APS免疫病理过程的发生与sCMA浓度升高有关。
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