Reid G, Denger S, Kos M, Gannon F
European Molecular Biology Laboratory, EMBL, Heidelberg, Germany.
Cell Mol Life Sci. 2002 May;59(5):821-31. doi: 10.1007/s00018-002-8470-2.
This review aims to evaluate the impact that human estrogen receptor-alpha (ER-alpha) synthesis, modification and degradation has on estrogen-dependant physiological and pathological processes within the body. Estrogen signaling is transduced through estrogen receptors, which act as ligand-inducible transcription factors. The significance of different isoforms of ER-alpha that lack structural features of full-length ER-alpha are discussed. The influence of differential promoter usage on the amount and isoform of ER-alpha within individual cell types is also reviewed. Moreover, the potential role of phosphorylation, ubiquitination and acetylation in the function and dynamic turnover of ER-alpha is presented.
本综述旨在评估人类雌激素受体α（ER-α）的合成、修饰和降解对体内雌激素依赖性生理和病理过程的影响。雌激素信号通过作为配体诱导型转录因子的雌激素受体进行转导。文中讨论了缺乏全长ER-α结构特征的不同ER-α亚型的意义。还综述了不同启动子使用对个体细胞类型中ER-α数量和亚型的影响。此外，还介绍了磷酸化、泛素化和乙酰化在ER-α功能和动态周转中的潜在作用。
