Lindberg M, Hole A, Johnsen H, Asberg A, Rydning A, Myrvold H E, Bjerve K S
Department of Clinical Chemistry, Trondheim University Hospital, Norway.
Scand J Clin Lab Invest. 2002;62(3):189-94. doi: 10.1080/003655102317475443.
Procalcitonin (PCT). a new marker proposed as a diagnostic tool for bacterial infections, triggers a systemic-inflammatory reaction in the body (sepsis, septic shock) and has potential use in a wide range of patient settings. To interpret the results from PCT measurements, we depend on reference intervals established from relevant populations. PCT and C-reactive protein (CRP) concentrations were analysed in 47 patients with a normal postoperative course after major abdominal surgery. The mean concentration of PCT declines from the first day and reaches half its initial values on the second day after the operation. whereas the mean concentration of CRP increases in the first 48 h and reaches half its maximum value on the fifth day after the operation. We present a continuous reference interval for plasma PCT and CRP concentrations in the first week following major abdominal surgery. For PCT we also present a graphic display of expected mean and expected upper reference limits predicted from the value measured on the first postoperative day.
降钙素原（PCT），一种被提议作为细菌感染诊断工具的新标志物，会引发身体的全身炎症反应（脓毒症、感染性休克），并且在广泛的患者群体中具有潜在用途。为了解释PCT测量结果，我们依赖于从相关人群中建立的参考区间。对47例腹部大手术后术后病程正常的患者进行了PCT和C反应蛋白（CRP）浓度分析。PCT的平均浓度从第一天开始下降，在术后第二天降至初始值的一半，而CRP的平均浓度在最初48小时内升高，并在术后第五天达到最大值的一半。我们给出了腹部大手术后第一周血浆PCT和CRP浓度的连续参考区间。对于PCT，我们还给出了根据术后第一天测量值预测的预期均值和预期参考上限的图形展示。
