Rosenthal M A, Ashley D L, Cher L
Department of Medical Oncology and Clinical Haematology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Intern Med J. 2002 Jul;32(7):346-8. doi: 10.1046/j.1445-5994.2002.00242.x.
A transient deterioration in neurological status following commencement of chemotherapy for high-grade gliomas has not been previously described. We report eight cases of transient deterioration following administration of temozolomide, a relatively new cytotoxic agent used in the treatment of high-grade gliomas. We believe this represents the novel clinical entity of temozolomide-induced tumour flare.
高级别胶质瘤化疗开始后出现的短暂神经功能状态恶化此前未见报道。我们报告了8例在使用替莫唑胺（一种用于治疗高级别胶质瘤的相对较新的细胞毒性药物）后出现短暂恶化的病例。我们认为这代表了替莫唑胺诱导的肿瘤发作这一新的临床实体。
