Alam Naseer, Wang Weihong, Hong Jongki, Lee Chong-Ok, Im Kwang Sik, Jung Jee H
College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
J Nat Prod. 2002 Jun;65(6):944-5. doi: 10.1021/np010312v.
Two new sphingosine 4-sulfates (1 and 2) have been isolated from the sponge Spirastrella abata as cytotoxic constituents. The gross structures of 1 and 2 were determined by spectroscopic analysis, and their stereochemistry was established by chemical conversion. The compounds exhibited significant cytotoxicity against a small panel of five human tumor cell lines.
从海绵动物阿氏螺旋星衫鱼中分离出了两种新的4-硫酸鞘氨醇（1和2）作为细胞毒性成分。通过光谱分析确定了1和2的总体结构，并通过化学转化确定了它们的立体化学。这些化合物对一小部分五种人类肿瘤细胞系表现出显著的细胞毒性。
