Omeroglu Atilla, Paner Gladell P, Wojcik Eva M, Siziopikou Kalliopi
Department of Pathology, Loyola University Medical Center, Maywood, IL, USA.
Arch Pathol Lab Med. 2002 Jul;126(7):853-5. doi: 10.5858/2002-126-0853-ACSCAI.
We describe an invasive polypoid carcinosarcoma/sarcomatoid carcinoma arising within a urinary bladder diverticulum in a 65-year-old patient with synchronous, moderately differentiated prostatic adenocarcinoma. Histologically, the diverticular tumor exhibits an admixture of different morphologic components, including invasive high-grade urothelial carcinoma, malignant glandular structures in a cellular background of malignant spindle cells, and areas formed exclusively by spindle and pleomorphic cells. There was full-thickness involvement of the diverticulum with extension of the tumor into the perivesical fat and ipsilateral seminal vesicle. In view of the early invasive behavior of carcinosarcoma/sarcomatoid carcinoma combined with the paucity of the muscular layer in the diverticulum wall, a graver prognosis was expected for this aggressive tumor that occurred in this unusual site.
我们描述了一例发生于膀胱憩室内的侵袭性息肉样癌肉瘤/肉瘤样癌，患者为65岁男性，同时患有中度分化的前列腺腺癌。组织学上，憩室肿瘤呈现出不同形态成分的混合，包括侵袭性高级别尿路上皮癌、在恶性梭形细胞的细胞背景中的恶性腺结构，以及仅由梭形和多形性细胞形成的区域。憩室出现全层受累，肿瘤延伸至膀胱周围脂肪和同侧精囊。鉴于癌肉瘤/肉瘤样癌的早期侵袭行为，以及憩室壁肌层稀少，预计发生在这个不寻常部位的这种侵袭性肿瘤预后更差。
