Fonteneau Jean François, Larsson Marie, Bhardwaj Nina
Laboratory of Molecular Neuro-Oncology, The Rockefeller University New York, New York, NY 10021, USA.
Curr Opin Immunol. 2002 Aug;14(4):471-7. doi: 10.1016/s0952-7915(02)00358-8.
Dendritic cells - professional antigen-presenting cells - are key players for activating adaptive immune responses against viruses. Apoptosis or lytic cell death often accompanies viral infection. Dendritic cells can acquire infected dead or dying cells as exogenous sources of antigens for presentation on MHC class I and II molecules to initiate T cell responses. This pathway of activating T cells may be critical for the development of effective antiviral immunity in vivo.
树突状细胞——专业的抗原呈递细胞——是激活针对病毒的适应性免疫反应的关键参与者。细胞凋亡或溶解性细胞死亡常伴随病毒感染。树突状细胞可以获取受感染的死亡或濒死细胞作为抗原的外源性来源，以便在MHC I类和II类分子上呈递，从而启动T细胞反应。这种激活T细胞的途径可能对体内有效抗病毒免疫的发展至关重要。
