消炎痛和前列腺素F2α对仓鼠分娩的影响。

Effects of indomethacin and prostaglandin F2alpha on parturition in the hamster.

作者信息

Lau I F, Saksena S K, Chang M C

出版信息

Prostaglandins. 1975 Dec;10(6):1011-8. doi: 10.1016/s0090-6980(75)80048-7.

PMID:1208879

Abstract

In the hamster administration of indomethacin twice a day on days 14 to 16 of pregnancy delayed the onset of parturition; a delay of 5 and 8 hours was observed following treatments of 300 or 600 mug/injection of indomethacin, respectively. Injection of PGF2alpha to the indomethacin treated hamsters on day 15 of pregnancy, on the other hand, advanced the onset of parturition. Treatments of indomethacin and/or PGF2alpha did not affect the duration of parturition.

摘要

在妊娠第14至16天，每天给仓鼠两次吲哚美辛，可延迟分娩开始；分别注射300或600微克/注射剂量的吲哚美辛后，观察到延迟时间分别为5小时和8小时。另一方面，在妊娠第15天给接受吲哚美辛治疗的仓鼠注射PGF2α，可提前分娩开始。吲哚美辛和/或PGF2α治疗不影响分娩持续时间。