Paoletti Lawrence C, Kasper Dennis L
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
J Infect Dis. 2002 Jul 1;186(1):123-6. doi: 10.1086/341073. Epub 2002 Jun 14.
Although rarely encountered, group B Streptococcus (GBS) types IV and VII have been isolated from infants and adults with invasive disease. This study was designed to determine the immunogenicity and efficacy in animals of conjugate vaccines prepared with GBS types IV and VII capsular polysaccharide (CPS). Despite the striking similarities in structure of these 2 carbohydrate antigens, high-titer rabbit antiserum to each conjugate vaccine was serotype specific. Active vaccination of female mice with the conjugate vaccines induced type-specific IgG and resulted in survival of >90% of newborn pups challenged with viable GBS of homologous serotype. If needed, types IV and VII CPS conjugate vaccines of the design described can be added to the formulation of a multivalent GBS vaccine.
虽然B族链球菌（GBS）IV型和VII型很少见，但已从患有侵袭性疾病的婴儿和成人中分离出来。本研究旨在确定用GBS IV型和VII型荚膜多糖（CPS）制备的结合疫苗在动物中的免疫原性和功效。尽管这两种碳水化合物抗原在结构上有惊人的相似之处，但针对每种结合疫苗的高滴度兔抗血清具有血清型特异性。用结合疫苗对雌性小鼠进行主动免疫可诱导产生型特异性IgG，并使>90%受到同源血清型活GBS攻击的新生幼崽存活。如有需要，所述设计的IV型和VII型CPS结合疫苗可添加到多价GBS疫苗的配方中。
