Kosmala Wojciech
Katedra i Klinika Kardiologii AM we Wrocławiu.
Pol Merkur Lekarski. 2002 Apr;12(70):333-5.
Endothelial cells produce both vasodilatating compounds as nitric oxide, prostacycline, endothelial derived hyperpolarising factor and counteracting substances known as endothelial derived contracting factors: endothelin, tromboxan A2, prostaglandin H2, free oxygen radicals. Natural balance between both groups affects blood perfusion of various tissues and constitutes important element in blood pressure control. More and more attention is paid to endothelial dysfunction in patogenesis of hypertension. In a number of studies endothelial dysfunction in hypertensive patients was found out as decreased release of nitric oxide or increased production of endothelin. Principle mechanism of impaired function of endothelium in hypertension seems to be decreased production and increased degradation of nitric oxide mainly due to free oxygen radicals. Favorable effects in improvement of endothelial function were achieved by using ACE inhibitors, AT1 receptor blockers and calcium channel antagonists.
内皮细胞产生诸如一氧化氮、前列环素、内皮衍生超极化因子等血管舒张化合物以及被称为内皮衍生收缩因子的拮抗物质：内皮素、血栓素A2、前列腺素H2、游离氧自由基。这两类物质之间的自然平衡影响着各种组织的血液灌注，并构成血压控制中的重要因素。在高血压发病机制中，内皮功能障碍越来越受到关注。在多项研究中，发现高血压患者的内皮功能障碍表现为一氧化氮释放减少或内皮素产生增加。高血压中内皮功能受损的主要机制似乎是一氧化氮的产生减少和降解增加，主要原因是游离氧自由基。使用血管紧张素转换酶抑制剂、AT1受体阻滞剂和钙通道拮抗剂可对改善内皮功能产生有益作用。
