Colev V, Popârda O, Mocanu V
Faculté de Médecine Département de Physiopathologie, Université de Médecine et de Pharmacie Gr.T. Popa Iasi.
Rev Med Chir Soc Med Nat Iasi. 2000 Jul-Sep;104(3):57-62.
We have studied the effects exerted by the angiotensin converting enzyme inhibitor (ACEI) Enalapril upon the glycemic profile in diabetic rats. With respect to the subacute character of our experiment (15 days), the following parameters have been recorded: diuresis, glycosuria, ketonuria and glycemia. In the diabetic rats treated with ACEI we haven noted slight, statistically insignificant improvements in glycosuria and glycemia, compared to the untreated diabetic subjects. Conversely, a statistically significant improvement of ketonuria has been noted in the diabetic rats receiving ACEI compared to the untreated ones. The short-term administration of ACEI in experimental diabetes mellitus acutely improves the glycemic profile, probably by the amelioration of the tissular sensitivity to insulin.
我们研究了血管紧张素转换酶抑制剂（ACEI）依那普利对糖尿病大鼠血糖状况的影响。关于我们实验的亚急性特征（15天），记录了以下参数：尿量、糖尿、酮尿和血糖。与未治疗的糖尿病大鼠相比，接受ACEI治疗的糖尿病大鼠在糖尿和血糖方面有轻微改善，但在统计学上无显著意义。相反，与未治疗的大鼠相比，接受ACEI治疗的糖尿病大鼠的酮尿有统计学上的显著改善。在实验性糖尿病中短期给予ACEI可急性改善血糖状况，这可能是通过改善组织对胰岛素的敏感性实现的。
