[智利康塞普西翁市各药房储存期间阿司匹林肠溶片化学稳定性的研究]
[Study of the chemical stability of acetylsalicylic acid tablets during storage in pharmacies of Concepción, Chile].
作者信息
Mennickent Sigrid, Yates Tamara, Vega Mario, Gloria Godoy C, Saelzer Roberto
机构信息
Departamentos de Farmacia y Bromatología, Nutrición y Dietética, Facultad de Farmacia, Universidad de Concepción, Casilla 237 Concepción, Chile.
出版信息
Rev Med Chil. 2002 Apr;130(4):409-15.
BACKGROUND
The chemical stability of a pharmaceutical product depends, among other factors, on environmental factors during transport, storage and manipulation of the product.
AIM
To study the chemical stability of acetylsalicylic acid (AAS) tablets during ten months of storage in five pharmacies of Concepción, Chile.
MATERIAL AND METHODS
Tablets were randomly collected at the beginning of the study and at the third, sixth and tenth month. Quantitative analyses of AAS tablets was carried out by instrumental thin layer chromatography (HPTLC).
RESULTS
AAS in tablets was between 99 and 109% at the beginning of the study, between 76 and 110% at three months, between 71% and 112% at six months and between 86 and 110% at ten months of storage.
CONCLUSIONS
There was a progressive decrease in the content of acetylsalicylic acid in tables during storage, but it remained between the limits accepted by the United States Pharmacopoeia (USP) (90-110%).
背景
药品的化学稳定性除其他因素外，还取决于产品运输、储存和操作过程中的环境因素。
目的
研究乙酰水杨酸（AAS）片剂在智利康塞普西翁市五家药店储存十个月期间的化学稳定性。
材料与方法
在研究开始时以及第三个月、第六个月和第十个月随机收集片剂。通过仪器薄层色谱法（HPTLC）对AAS片剂进行定量分析。
结果
研究开始时片剂中的AAS含量在99%至109%之间，储存三个月时在76%至110%之间，六个月时在71%至112%之间，十个月时在86%至110%之间。
结论
储存期间片剂中乙酰水杨酸的含量逐渐下降，但仍在美国药典（USP）认可的限度（90%-110%）之内。
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