LeBlanc Andrea
The Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada.
Curr Opin Investig Drugs. 2002 May;3(5):768-73.
The potential of estrogen as a therapeutic intervention in the prevention or treatment of neurodegenerative diseases has been the object of much research in the past five years. While clinical research has produced highly diverse results in different studies, basic research has uncovered a number ofmolecular mechanisms which dearly label estrogen as a neuroprotective agent. This short review summarizes the various research results that indicate how estrogen can be beneficial to neurons in Alzheimer's disease.
在过去五年中，雌激素作为预防或治疗神经退行性疾病的一种治疗干预手段的潜力一直是众多研究的对象。虽然临床研究在不同的研究中产生了高度多样化的结果，但基础研究已经揭示了一些分子机制，这些机制明确地将雌激素标记为一种神经保护剂。这篇简短的综述总结了各种研究结果，这些结果表明雌激素如何对阿尔茨海默病中的神经元有益。
