脑血清锂比值与年龄：一项活体磁共振波谱研究
Brain-to-serum lithium ratio and age: an in vivo magnetic resonance spectroscopy study.
作者信息
Moore Constance M, Demopulos Christina M, Henry Michael E, Steingard Ronald J, Zamvil Linda, Katic Alain, Breeze Janis L, Moore JoEllyn C, Cohen Bruce M, Renshaw Perry F
机构信息
Brain Imaging Center, Consolidated Department of Psychiatry, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.
出版信息
Am J Psychiatry. 2002 Jul;159(7):1240-2. doi: 10.1176/appi.ajp.159.7.1240.
Abstract
OBJECTIVE
The authors' goal was to determine if there is an association between brain-to-serum lithium ratios and age.
METHOD
Lithium-7 magnetic resonance spectroscopy was used to measure in vivo brain lithium levels in nine children and adolescents (mean age=13.4 years, SD=3.6) and 18 adults (mean age=37.3, SD=9.1) with bipolar disorder.
RESULTS
Serum and brain lithium concentrations were positively correlated. Younger subjects had lower brain-to-serum concentration ratios than adults: 0.58 (SD=0.24) versus 0.92 (SD=0.36). The brain-to-serum concentration ratio correlated positively with age.
CONCLUSIONS
These observations suggest that children and adolescents may need higher maintenance serum lithium concentrations than adults to ensure that brain lithium concentrations reach therapeutic levels.
摘要
目的
作者的目标是确定脑锂与血清锂的比值和年龄之间是否存在关联。
方法
采用锂 - 7磁共振波谱法测量9名儿童和青少年（平均年龄 = 13.4岁，标准差 = 3.6）以及18名双相情感障碍成人（平均年龄 = 37.3岁，标准差 = 9.1）的体内脑锂水平。
结果
血清锂浓度与脑锂浓度呈正相关。较年轻的受试者脑锂与血清锂的浓度比值低于成年人：分别为0.58（标准差 = 0.24）和0.92（标准差 = 0.36）。脑锂与血清锂的浓度比值与年龄呈正相关。
结论
这些观察结果表明，儿童和青少年可能需要比成年人更高的血清锂维持浓度，以确保脑锂浓度达到治疗水平。
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