脑血清锂比值与年龄：一项活体磁共振波谱研究
Brain-to-serum lithium ratio and age: an in vivo magnetic resonance spectroscopy study.
作者信息
Moore Constance M, Demopulos Christina M, Henry Michael E, Steingard Ronald J, Zamvil Linda, Katic Alain, Breeze Janis L, Moore JoEllyn C, Cohen Bruce M, Renshaw Perry F
机构信息
Brain Imaging Center, Consolidated Department of Psychiatry, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.
出版信息
Am J Psychiatry. 2002 Jul;159(7):1240-2. doi: 10.1176/appi.ajp.159.7.1240.
Abstract
OBJECTIVE
The authors' goal was to determine if there is an association between brain-to-serum lithium ratios and age.
METHOD
Lithium-7 magnetic resonance spectroscopy was used to measure in vivo brain lithium levels in nine children and adolescents (mean age=13.4 years, SD=3.6) and 18 adults (mean age=37.3, SD=9.1) with bipolar disorder.
RESULTS
Serum and brain lithium concentrations were positively correlated. Younger subjects had lower brain-to-serum concentration ratios than adults: 0.58 (SD=0.24) versus 0.92 (SD=0.36). The brain-to-serum concentration ratio correlated positively with age.
CONCLUSIONS
These observations suggest that children and adolescents may need higher maintenance serum lithium concentrations than adults to ensure that brain lithium concentrations reach therapeutic levels.
摘要
目的
作者的目标是确定脑锂与血清锂的比值和年龄之间是否存在关联。
方法
采用锂 - 7磁共振波谱法测量9名儿童和青少年（平均年龄 = 13.4岁，标准差 = 3.6）以及18名双相情感障碍成人（平均年龄 = 37.3岁，标准差 = 9.1）的体内脑锂水平。
结果
血清锂浓度与脑锂浓度呈正相关。较年轻的受试者脑锂与血清锂的浓度比值低于成年人：分别为0.58（标准差 = 0.24）和0.92（标准差 = 0.36）。脑锂与血清锂的浓度比值与年龄呈正相关。
结论
这些观察结果表明，儿童和青少年可能需要比成年人更高的血清锂维持浓度，以确保脑锂浓度达到治疗水平。
相似文献
1
Brain-to-serum lithium ratio and age: an in vivo magnetic resonance spectroscopy study.脑血清锂比值与年龄：一项活体磁共振波谱研究
Am J Psychiatry. 2002 Jul;159(7):1240-2. doi: 10.1176/appi.ajp.159.7.1240.
2
Brain lithium concentration by 7Li- and 1H-magnetic resonance spectroscopy in bipolar disorder.双相情感障碍中通过7Li和1H磁共振波谱法测定的脑锂浓度
Psychiatry Res. 1992 May;45(1):53-63. doi: 10.1016/0925-4927(92)90013-t.
3
Relationship of lithium concentrations in the brain measured by lithium-7 magnetic resonance spectroscopy to treatment response in mania.通过锂-7磁共振波谱法测量的大脑中锂浓度与躁狂症治疗反应的关系。
J Clin Psychopharmacol. 1994 Oct;14(5):330-5.
4
Measurement of tissue lithium concentration by lithium magnetic resonance spectroscopy in patients with bipolar disorder.双相情感障碍患者组织锂浓度的锂磁共振波谱测量。
Biol Psychiatry. 1991 Jun 15;29(12):1161-70. doi: 10.1016/0006-3223(91)90324-f.
5
Relaxation times and concentrations of 7Li in the brain of patients receiving lithium therapy.接受锂盐治疗的患者大脑中7Li的弛豫时间和浓度。
NMR Biomed. 1993 Jan-Feb;6(1):39-42. doi: 10.1002/nbm.1940060107.
6
Decreased anterior cingulate myo-inositol/creatine spectroscopy resonance with lithium treatment in children with bipolar disorder.双相情感障碍患儿锂治疗后前扣带回肌醇/肌酸磁共振波谱降低。
Neuropsychopharmacology. 2001 Apr;24(4):359-69. doi: 10.1016/S0893-133X(00)00207-4.
7
Brain lithium concentrations in bipolar disorder patients: preliminary (7)Li magnetic resonance studies at 3 T.双相情感障碍患者大脑中的锂浓度：3T场强下的初步（7）锂磁共振研究
Biol Psychiatry. 2001 Mar 1;49(5):437-43. doi: 10.1016/s0006-3223(00)00985-9.
8
A Selective Association between Central and Peripheral Lithium Levels in Remitters in Bipolar Depression: A 3T-(7) Li Magnetic Resonance Spectroscopy Study.双相抑郁症缓解期患者中枢与外周锂水平之间的选择性关联：一项3T - （7）锂磁共振波谱研究
Acta Psychiatr Scand. 2016 Mar;133(3):214-20. doi: 10.1111/acps.12511. Epub 2015 Oct 29.
9
Lithium in bipolar disorder: can drug concentrations predict therapeutic effect?双相情感障碍中的锂盐：药物浓度能否预测治疗效果？
Clin Pharmacokinet. 2002;41(9):639-60. doi: 10.2165/00003088-200241090-00002.
10
Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data.锂血清水平从标准值急剧降至低水平的影响：双盲锂维持治疗数据的重新分析
Am J Psychiatry. 2002 Jul;159(7):1155-9. doi: 10.1176/appi.ajp.159.7.1155.
引用本文的文献
1
The Bipolar Lithium Imaging Scan Study (BLISS): protocol for a 7T lithium-7 magnetic resonance study in bipolar disorder.双相情感障碍锂成像扫描研究（BLISS）：一项针对双相情感障碍的7T锂-7磁共振研究方案
Psychoradiology. 2025 Mar 7;5:kkaf003. doi: 10.1093/psyrad/kkaf003. eCollection 2025.
2
Relevance of red blood cell Lithium concentration in the management of Lithium-treated bipolar and unipolar disorders: a systematic narrative review.红细胞锂浓度在锂盐治疗双相和单相情感障碍中的相关性：一项系统的叙述性综述
Int J Bipolar Disord. 2024 Oct 16;12(1):35. doi: 10.1186/s40345-024-00356-5.
3
Position sensitive measurement of trace lithium in the brain with NIK (neutron-induced coincidence method) in suicide.利用 NIK（中子诱导符合法）对自杀者脑中痕量锂进行位置敏感测量。
Sci Rep. 2021 Mar 25;11(1):6823. doi: 10.1038/s41598-021-86377-x.
4
In vivo evaluation of the effect of lithium on peripheral circadian clocks by real-time monitoring of clock gene expression in near-freely moving mice.在近自由活动的小鼠中实时监测时钟基因表达，评估锂对周围昼夜节律钟的体内影响。
Sci Rep. 2019 Jul 29;9(1):10909. doi: 10.1038/s41598-019-47053-3.
5
An observational study of 110 elderly lithium-treated patients followed up for 6 years with particular reference to renal function.一项对110名接受锂治疗的老年患者进行的观察性研究，随访6年，特别关注肾功能。
Int J Bipolar Disord. 2017 Dec;5(1):19. doi: 10.1186/s40345-017-0089-1. Epub 2017 Jul 9.
6
High-Speed imaging reveals opposing effects of chronic stress and antidepressants on neuronal activity propagation through the hippocampal trisynaptic circuit.高速成像揭示了慢性应激和抗抑郁药对通过海马三突触回路的神经元活动传播的相反作用。
Front Neural Circuits. 2015 Nov 6;9:70. doi: 10.3389/fncir.2015.00070. eCollection 2015.
7
Lithium: updated human knowledge using an evidence-based approach. Part II: Clinical pharmacology and therapeutic monitoring.锂：采用循证方法更新人类知识。第二部分：临床药理学与治疗监测。
CNS Drugs. 2009;23(4):331-49. doi: 10.2165/00023210-200923040-00005.
8
Randomized double-blind placebo-controlled trial of lithium in youths with severe mood dysregulation.锂盐治疗严重情绪失调青少年的随机双盲安慰剂对照试验。
J Child Adolesc Psychopharmacol. 2009 Feb;19(1):61-73. doi: 10.1089/cap.2008.044.
9
Effect of divalproex on brain morphometry, chemistry, and function in youth at high-risk for bipolar disorder: a pilot study.丙戊酸镁对双相情感障碍高危青少年脑形态学、化学及功能的影响：一项初步研究。
J Child Adolesc Psychopharmacol. 2009 Feb;19(1):51-9. doi: 10.1089/cap.2008.060.
10
Brain lithium, N-acetyl aspartate and myo-inositol levels in older adults with bipolar disorder treated with lithium: a lithium-7 and proton magnetic resonance spectroscopy study.锂盐治疗的老年双相情感障碍患者脑内锂、N-乙酰天门冬氨酸和肌醇水平：一项锂-7和质子磁共振波谱研究
Bipolar Disord. 2008 Sep;10(6):691-700. doi: 10.1111/j.1399-5618.2008.00627.x.
本文引用的文献
1
AACAP official action. Summary of the practice parameters for the assessment and treatment of children and adolescents with schizophrenia. American Academy of Child and Adolescent Psychiatry.美国儿童青少年精神病学会官方行动。儿童和青少年精神分裂症评估与治疗实践参数总结。美国儿童青少年精神病学会。
J Am Acad Child Adolesc Psychiatry. 2000 Dec;39(12):1580-2. doi: 10.1097/00004583-200012000-00027.
2
In vivo imaging of the pharmacodynamics and pharmacokinetics of lithium.锂的药效学和药代动力学的体内成像
J Clin Psychiatry. 2000;61 Suppl 9:41-6.
3
Applications of (7)Li NMR in biomedicine.
Magn Reson Imaging. 2000 Feb;18(2):103-16. doi: 10.1016/s0730-725x(99)00116-2.
4
The ups and downs of oral lithium dosing.
J Clin Psychiatry. 1998;59 Suppl 6:21-6; discussion 27.
5
Sodium-lithium countertransport: physiology and function.
J Hypertens. 1998 Jan;16(1):3-13. doi: 10.1097/00004872-199816010-00002.
6
Low rate of membrane lithium transport during treatment correlates with outcome of maintenance pharmacotherapy in bipolar disorder.
Neuropsychopharmacology. 1997 May;16(5):325-32. doi: 10.1016/S0893-133X(96)00241-2.
7
MR quantification of cerebral ventricular volume using a semiautomated algorithm.使用半自动算法对脑室容积进行磁共振定量分析。
AJNR Am J Neuroradiol. 1993 Nov-Dec;14(6):1373-8.
8
Measurement of human brain lithium in vivo by MR spectroscopy.通过磁共振波谱法在体内测量人脑锂含量。
AJNR Am J Neuroradiol. 1993 Sep-Oct;14(5):1027-37.
9
24-hour lithium concentration in human brain studied by Li-7 magnetic resonance spectroscopy.
Biol Psychiatry. 1994 Oct 15;36(8):511-6. doi: 10.1016/0006-3223(94)90614-9.
10
Pharmacokinetics of lithium carbonate in children.
J Clin Psychopharmacol. 1988 Oct;8(5):355-9.
Zotero 插件