Kato T, Takahashi S, Inubushi T
Department of Psychiatry, Shiga University of Medical Science, Japan.
Psychiatry Res. 1992 May;45(1):53-63. doi: 10.1016/0925-4927(92)90013-t.
A method was developed to measure lithium concentrations in the human brain using in vivo 7Li- and 1H-magnetic resonance spectroscopy (MRS). Lithium concentrations measured by MRS in 10 lithium-treated bipolar patients were at the half level of those measured in serum. Serial measurements indicated that lithium concentrations in the brain increased markedly during manic episodes, while serum concentrations were unchanged. These findings suggest that in vivo measurements of lithium concentrations in the brain, combined with measurements of concentrations in serum, may be useful in monitoring the effects of therapeutic drugs.
一种利用体内7Li和1H磁共振波谱（MRS）测量人脑锂浓度的方法被开发出来。通过MRS测量的10名接受锂治疗的双相情感障碍患者的脑内锂浓度仅为血清中测量浓度的一半。连续测量表明，躁狂发作期间脑内锂浓度显著升高，而血清浓度未变。这些发现表明，结合血清浓度测量对脑内锂浓度进行体内测量，可能有助于监测治疗药物的效果。
