Kecskes Z, Cartwright D W
Royal Children's Hospital Foundation, Royal Children's Hospital, Herston Road, Herston, Queensland, Australia.
Arch Dis Child Fetal Neonatal Ed. 2002 Jul;87(1):F31-3. doi: 10.1136/fn.87.1.f31.
To evaluate incidence and mortality of congenital heart disease in very low birthweight babies.
Retrospective analysis of a 12 year period.
Forty seven babies were diagnosed with severe congenital heart disease. The most common lesions were ventricular septal defect and coarctation of the aorta. Mortality attributed to congenital heart disease was 32%. Coarctation of the aorta, the second most common lesion, was fatal in 62% of cases. Closure of a patent ductus arteriosus with indomethacin proved to be detrimental in babies with undiagnosed coarctation, causing rapid deterioration in some.
Very low birthweight neonates with severe congenital heart disease have a higher mortality than babies with higher birth weight. A contributing factor is closure of a patent ductus arteriosus if an underlying lesion has not been recognised. This could be of significance if the use of prophylactic treatment with indomethacin becomes more common.
评估极低出生体重儿先天性心脏病的发病率和死亡率。
对12年期间的数据进行回顾性分析。
47例婴儿被诊断患有严重先天性心脏病。最常见的病变是室间隔缺损和主动脉缩窄。先天性心脏病导致的死亡率为32%。主动脉缩窄是第二常见的病变，62%的病例死亡。事实证明，对未诊断出主动脉缩窄的婴儿使用吲哚美辛关闭动脉导管未闭是有害的，会导致一些婴儿病情迅速恶化。
患有严重先天性心脏病的极低出生体重新生儿的死亡率高于出生体重较高的婴儿。一个促成因素是在未识别潜在病变的情况下关闭动脉导管未闭。如果吲哚美辛预防性治疗的使用变得更加普遍，这可能具有重要意义。
