Yoon Hyo-Chun, Emerick Aletha M, Hill Jennifer A, Gjertson David W, Goldin Jonathan G
Department of Diagnostic Imaging, Kaiser Moanalua Medical Center, 3288 Moanalua Rd, Honolulu, HI 96819, USA.
Radiology. 2002 Jul;224(1):236-41. doi: 10.1148/radiol.2241011191.
To test the hypothesis that the rate of coronary artery calcium progression is sex specific, namely, that it is greater in men than in women, and that it is age related, particularly in women.
This was a retrospective study of the progression of coronary artery calcium in 217 consecutive asymptomatic subjects who underwent at least two electron-beam computed tomographic studies of the heart. Calcium in the distribution of the epicardial arteries was quantified by using both the conventional coronary artery calcium score (CCS) and the calcium volume score (CVS). Linear regression models were used to judge the joint influence of various risk factors, including sex and age, on rates of coronary artery calcium progression.
This study included 103 women and 114 men. The mean interval between the subjects' first and last studies was 25 months +/- 11 (SD). Regression analyses clearly demonstrated that the amount of coronary artery calcium present at the initial study was the most important determinant of calcium progression. This was true when coronary artery calcium was quantified by using the conventional CCS (P <.001) or CVS (P <.001). Neither sex nor age was a significant predictor of coronary artery calcium progression. Among traditional risk factors, only hypertension (P =.02) and diabetes (P =.01) were significant independent factors for calcium progression.
In asymptomatic subjects, the initial CCS and CVS were the most important factors that affected rate of coronary artery calcium progression. Neither age nor sex was as important as these factors in determination of coronary artery calcium progression.
检验以下假设，即冠状动脉钙化进展速率具有性别特异性，也就是说男性的进展速率高于女性，并且该速率与年龄相关，尤其是在女性中。
这是一项对217例连续无症状受试者冠状动脉钙化进展情况的回顾性研究，这些受试者至少接受了两次心脏电子束计算机断层扫描研究。通过使用传统冠状动脉钙化评分（CCS）和钙体积评分（CVS）对心外膜动脉分布区域的钙化进行量化。采用线性回归模型来判断包括性别和年龄在内的各种风险因素对冠状动脉钙化进展速率的联合影响。
本研究纳入了103名女性和114名男性。受试者首次和末次研究之间的平均间隔为25个月±11（标准差）。回归分析清楚地表明，初始研究时存在的冠状动脉钙化量是钙化进展的最重要决定因素。当使用传统CCS（P<.001）或CVS（P<.001）对冠状动脉钙化进行量化时，情况都是如此。性别和年龄均不是冠状动脉钙化进展的显著预测因素。在传统风险因素中，只有高血压（P =.02）和糖尿病（P =.01）是钙化进展的显著独立因素。
在无症状受试者中，初始CCS和CVS是影响冠状动脉钙化进展速率的最重要因素。在确定冠状动脉钙化进展方面，年龄和性别都不如这些因素重要。
