Testini M, Nacchiero M, Miniello S, Piccinni G, Di Venere B, Lissidini G, Bussetta E, Bonomo G M
Section of General Vascular and Clinical Oncology, Department of Application in Surgery of Innovative Technologies, University of Bari, Bari, Italy.
Minerva Endocrinol. 2002 Sep;27(3):225-9.
The aim of this randomized controlled trial is to evaluate the feasibility of one-day thyroidectomy, comparing the results of this method vs standard thyroidectomy.
From June 2000 to June 2001, 110 patients underwent total thyroidectomy under general anesthesia for thyroid disease. The patients were randomized into 2 groups: in group A (40 patients) we used the one-day thyroidectomy; in group B (70 patients) we employed standard thyroidectomy. In both groups postoperative mobilization was immediate and the mean postoperative hospitalization stay was 21 hours (range: 18-24) in group A and 60 hours (range: 21-120) in group B. The mean follow-up was 10 months (range: 6-18 months).
The patients of group A showed hypoparathyroidism with temporary hypocalcaemia in 3 cases (7.5%) vs 5 (7.1%) of group B; this finding was not statistically significant. No cases of definitive hypoparathyroidism, nor lesions of RLN, of the external branches of the superior laryngeal nerve, nor postoperative hemorrhage were observed in either group.
The one-day thyroidectomy was found to be a safe, feasible and cost effective procedure, it is convenient for both the patient and the surgeon, and offers the same immediate and long-term results as the standard thyroidectomy in selected patients.
本随机对照试验的目的是评估一日甲状腺切除术的可行性，比较该方法与标准甲状腺切除术的结果。
2000年6月至2001年6月，110例因甲状腺疾病在全身麻醉下接受全甲状腺切除术的患者。患者被随机分为两组：A组（40例患者）采用一日甲状腺切除术；B组（70例患者）采用标准甲状腺切除术。两组术后均立即活动，A组术后平均住院时间为21小时（范围：18 - 24小时），B组为60小时（范围：21 - 120小时）。平均随访时间为10个月（范围：6 - 18个月）。
A组患者中有3例（7.5%）出现甲状旁腺功能减退伴暂时性低钙血症，B组有5例（7.1%）；这一发现无统计学意义。两组均未观察到永久性甲状旁腺功能减退病例、喉返神经损伤、喉上神经外支损伤及术后出血。
一日甲状腺切除术是一种安全、可行且具有成本效益的手术，对患者和外科医生都很方便，并且在选定患者中与标准甲状腺切除术具有相同的近期和远期效果。
