Jorgensen F S
Scand J Urol Nephrol. 1975;9(3):243-8. doi: 10.3109/00365597509134220.
Only about 20% of renal stone cases have an unquestionable cause such as hyperparathyroidism, renal tubular acidosis etc. explaining their stone formation. About 20-40% are believed to result from idiopathic hypercalciuria. The purpose of the present investigation was to study the renal excretion of calcium, magnesium, sodium and phosphate in 47 consecutive men with recurring renal stone formation without a demonstrable underlining metabolic disease and, for comparison, 43 normal men. The results are related to previous hypotheses on renal stone formation. No difference in urinary calcium (either concentration or excretion) per day is found between the two groups. Consequently the concept of idiopathic hypercalciuria is questioned. The Mg/Ca ratio in urine is found lower in the stone patients than in the controls, suggesting that the Mg/Ca ratio might be of importance in stone formation.
只有约20%的肾结石病例有明确病因，如甲状旁腺功能亢进、肾小管酸中毒等，这些病因可以解释结石的形成。约20% - 40%的病例被认为是特发性高钙尿症所致。本研究的目的是研究47例连续复发肾结石且无明显潜在代谢疾病的男性以及43例正常男性的肾脏钙、镁、钠和磷酸盐排泄情况。研究结果与先前关于肾结石形成的假说相关。两组之间每日尿钙（浓度或排泄量）没有差异。因此，特发性高钙尿症的概念受到质疑。结石患者尿液中的镁钙比低于对照组，这表明镁钙比可能在结石形成中起重要作用。
