Carstensen H E
Scand J Thorac Cardiovasc Surg. 1975;9(3):200-5. doi: 10.3109/14017437509138640.
The purpose of the present study was to establish viability criteria for hearts perfused with a non-biological synthetic perfusate in a Langendorff type preparation. During hypothermic perfusion, the only discriminant between eight undamaged and four hypoxically damaged hearts was resistance to perfusion flow. At near normothermic conditions, the damaged hearts exhibited a decreased respiratory rate. It was also suggested that adrenalin stress of the isolated heart might be useful instead of orthotopic transplantation, as a final test of viability.
本研究的目的是在Langendorff型制备中，为用非生物合成灌注液灌注的心脏建立生存能力标准。在低温灌注期间，八个未受损心脏和四个缺氧受损心脏之间唯一的判别标准是对灌注流的阻力。在接近常温的条件下，受损心脏的呼吸频率降低。还提出，离体心脏的肾上腺素应激可能作为生存能力的最终测试，以替代原位移植。
