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[细胞凋亡的分子机制。Fas和肿瘤坏死因子系统。ICE蛋白酶系统。Bcl-2家族]

[Molecular mechanisms of apoptosis. Fas and TNF systems. ICE protease system. Bcl-2 family].

作者信息

Goga L M, Vasiliu O M, Ionescu C R

机构信息

Disciplina de Biologie Celulară şi Moleculară, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.

出版信息

Rev Med Chir Soc Med Nat Iasi. 2001 Jan-Mar;105(1):23-9.

PMID:12092154
Abstract

For every cell is a time to live and a time to die. The cell death that occurs during embryogenesis, normal tissue turnover, pathological conditions like cancer cells, etc. is "programmed cell death" or apoptosis. In this study we report on apoptosis mediated by cytokines. Fas ligand and tumor necrosis factor bind to their receptors and induce apoptosis.

摘要

每个细胞都有生之时与死之时。在胚胎发育、正常组织更新、诸如癌细胞等病理状况期间发生的细胞死亡是“程序性细胞死亡”或凋亡。在本研究中,我们报告了由细胞因子介导的凋亡。Fas配体和肿瘤坏死因子与其受体结合并诱导凋亡。

相似文献

1
[Molecular mechanisms of apoptosis. Fas and TNF systems. ICE protease system. Bcl-2 family].[细胞凋亡的分子机制。Fas和肿瘤坏死因子系统。ICE蛋白酶系统。Bcl-2家族]
Rev Med Chir Soc Med Nat Iasi. 2001 Jan-Mar;105(1):23-9.
2
Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways.肿瘤坏死因子相关凋亡诱导配体(TRAIL)的细胞内机制:通过线粒体依赖和非依赖途径诱导凋亡
Oncogene. 2001 Apr 19;20(17):2122-33. doi: 10.1038/sj.onc.1204282.
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Molecular signaling in death receptor and mitochondrial pathways of apoptosis (Review).细胞凋亡的死亡受体和线粒体途径中的分子信号传导(综述)
Int J Oncol. 2003 Jan;22(1):15-20.
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Thyroid carcinoma cells are resistant to FAS-mediated apoptosis but sensitive to tumor necrosis factor-related apoptosis-inducing ligand.甲状腺癌细胞对FAS介导的凋亡具有抗性,但对肿瘤坏死因子相关凋亡诱导配体敏感。
Cancer Res. 2000 Aug 1;60(15):4122-9.
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Apoptosis signaling pathways in normal T cells: differential activity of Bcl-2 and IL-1beta-converting enzyme family protease inhibitors on glucocorticoid- and Fas-mediated cytotoxicity.正常T细胞中的凋亡信号通路:Bcl-2和白细胞介素-1β转化酶家族蛋白酶抑制剂对糖皮质激素和Fas介导的细胞毒性的不同作用
J Immunol. 1996 Nov 1;157(9):3845-9.
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[Molecular mechanisms in apoptosis].[细胞凋亡的分子机制]
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Apoptosis: a case where too much or too little can lead to autoimmunity.细胞凋亡:过多或过少都可能导致自身免疫的一种情况。
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Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): caspase-8 is required for TRAIL-induced apoptosis.肿瘤坏死因子相关凋亡诱导配体(TRAIL)触发的信号事件:TRAIL诱导的凋亡需要半胱天冬酶-8。
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Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF.肿瘤坏死因子(TNF)受体2、CD40和CD30诱导细胞死亡:内源性膜锚定TNF激活TNF-R1的作用。
EMBO J. 1999 Jun 1;18(11):3034-43. doi: 10.1093/emboj/18.11.3034.
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Casein kinase I attenuates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by regulating the recruitment of fas-associated death domain and procaspase-8 to the death-inducing signaling complex.酪蛋白激酶I通过调节Fas相关死亡结构域和procaspase-8向死亡诱导信号复合物的募集来减弱肿瘤坏死因子相关凋亡诱导配体诱导的凋亡。
Cancer Res. 2004 Nov 1;64(21):8036-44. doi: 10.1158/0008-5472.CAN-04-0762.

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