[细胞凋亡的分子机制。Fas和肿瘤坏死因子系统。ICE蛋白酶系统。Bcl-2家族]
[Molecular mechanisms of apoptosis. Fas and TNF systems. ICE protease system. Bcl-2 family].
作者信息
Goga L M, Vasiliu O M, Ionescu C R
机构信息
Disciplina de Biologie Celulară şi Moleculară, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
出版信息
Rev Med Chir Soc Med Nat Iasi. 2001 Jan-Mar;105(1):23-9.
PMID:12092154
Abstract
For every cell is a time to live and a time to die. The cell death that occurs during embryogenesis, normal tissue turnover, pathological conditions like cancer cells, etc. is "programmed cell death" or apoptosis. In this study we report on apoptosis mediated by cytokines. Fas ligand and tumor necrosis factor bind to their receptors and induce apoptosis.
摘要
每个细胞都有生之时与死之时。在胚胎发育、正常组织更新、诸如癌细胞等病理状况期间发生的细胞死亡是“程序性细胞死亡”或凋亡。在本研究中，我们报告了由细胞因子介导的凋亡。Fas配体和肿瘤坏死因子与其受体结合并诱导凋亡。
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