Ciocoiu M, Fratu C, Bădescu L, Bădescu M
Disciplina de Fiziopatologie, Facultatea de Medicină, Universitate de Medicină şi Farmacie Gr.T. Popa Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2001 Jul-Sep;105(3):490-2.
Several different types of systems employing selectively permeable membranes and matrix supports for cells have been successfully tested in animals. Results in diabetic animals indicate that these systems can function for periods of several months to several years without the use of any of immunosuppression. This approach has the potential not only to allow the transplantation of islets across wide species barriers but that it can be achieved using injectable microreactors fabricated from biodegradable polymers. A new prototype of minimal volume alginate/polyaminoacidic microcapsules which retain immunoisolatory, biocompatibility and functional properties that seem to match those of conventional-size microcapsules was developed. Since coherent microcapsules tightly envelop each islet, any redundant space between membrane and islet is virtually eliminated. Consequently, these microcapsules occupy an extremely this space, thus addressing a major problem associated with conventional size microspheres.
几种采用选择性渗透膜和细胞基质支持物的不同类型系统已在动物身上成功进行了测试。糖尿病动物的实验结果表明，这些系统在不使用任何免疫抑制措施的情况下，能够运行数月至数年。这种方法不仅有可能实现跨物种屏障的胰岛移植，而且可以通过使用由可生物降解聚合物制成的可注射微反应器来实现。一种新型的最小体积藻酸盐/聚氨基酸微胶囊原型被开发出来，它保留了免疫隔离、生物相容性和功能特性，这些特性似乎与传统尺寸的微胶囊相当。由于连贯的微胶囊紧密包裹每个胰岛，膜与胰岛之间的任何多余空间实际上都被消除了。因此，这些微胶囊占据的空间极小，从而解决了与传统尺寸微球相关的一个主要问题。
